سعر AGOVALD 25 MG 21 F.C.TABS. 2026

Agovald 25 mg, 21 film-coated tablets of agomelatine (Mash Premiere); melatonergic antidepressant.

• Very common: headache. Common: dizziness, somnolence, insomnia, nausea, diarrhoea, constipation, abdominal pain, back pain, fatigue, anxiety, raised ALT/AST, weight gain.International label, equivalent formulation · European Medicines Agency (EMA)

• Hypersensitivity; hepatic impairment (cirrhosis or active liver disease) or transaminases >3x ULN; concomitant potent CYP1A2 inhibitors (e.g. fluvoxamine, ciprofloxacin).International label, equivalent formulation · European Medicines Agency (EMA)

• Liver injury including hepatic failure reported; stop if transaminases exceed 3x ULN or signs of liver injury occur. Suicidal thoughts risk; caution in bipolar disorder; not for dementia-related depression in the elderly; contains lactose.International label, equivalent formulation · European Medicines Agency (EMA)

• FluvoxaminePotent CYP1A2 inhibitor: about 60-fold increase in agomelatine exposure; contraindicated.European Medicines Agency (EMA)
• CiprofloxacinPotent CYP1A2 inhibitor; contraindicated.European Medicines Agency (EMA)
• Oestrogens, propranolol, enoxacinModerate CYP1A2 inhibitors increase exposure; use with caution.European Medicines Agency (EMA)

• Limited human data (<300 outcomes); animal studies show no harm; as a precaution avoid during pregnancy.International label, equivalent formulation · European Medicines Agency (EMA)
• Unknown whether excreted in human milk (excreted in animal milk); decide whether to stop breastfeeding or therapy.International label, equivalent formulation · European Medicines Agency (EMA)

• Agomelatine: Agonist at melatonergic MT1 and MT2 receptors and antagonist at 5-HT2C receptors; no effect on monoamine uptake.