سعر اميتريبتيين 50 مجم 30 قرص 2022

Amitriptyline 50 mg oral tablets (Amitriptine, Future Pharmaceutical Industries, Egypt), a tricyclic antidepressant; 30 tablets (3 strips).

• Relief of symptoms of depression; endogenous depression is more likely to be alleviated than other depressive states.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Anticholinergic effects (dry mouth, constipation, urinary retention, blurred vision, increased intraocular pressure), cardiovascular effects (hypotension, tachycardia, arrhythmias, heart block), CNS effects (sedation, confusion, dizziness), and rarely bone marrow depression are described in the label.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to amitriptyline.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Concomitant use with monoamine oxidase inhibitors (hyperpyretic crises, severe convulsions and deaths reported); allow at least 14 days after stopping an MAOI before starting.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Concomitant use with cisapride (risk of QT prolongation and arrhythmias).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: antidepressants increased the risk of suicidal thinking and behaviour in children, adolescents and young adults in short-term studies; monitor all patients for clinical worsening, suicidality and unusual behaviour changes, especially early in treatment and at dose changes. Not approved for use in paediatric patients.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serotonin syndrome may occur, particularly with other serotonergic drugs (triptans, SSRIs, SNRIs, lithium, tramadol, St John's wort, etc.).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Pupillary dilation may trigger angle-closure glaucoma in patients with anatomically narrow angles.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Monoamine oxidase inhibitorsContraindicated: hyperpyretic crises, severe convulsions and deaths; 14-day washout needed.DailyMed (U.S. National Library of Medicine)
• Drugs inhibiting CYP2D6 (e.g. quinidine, cimetidine, SSRIs such as fluoxetine, sertraline, paroxetine; phenothiazines, propafenone, flecainide)Can markedly increase tricyclic antidepressant concentrations and toxicity; lower TCA doses and monitoring may be required.DailyMed (U.S. National Library of Medicine)
• TopiramateSome patients show a large increase in amitriptyline concentration; adjust dose on clinical response.DailyMed (U.S. National Library of Medicine)

• No adequate and well-controlled studies in pregnant women; animal reproduction studies with high doses showed adverse effects. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Amitriptyline is excreted in human milk; because of potential serious adverse reactions in nursing infants, decide whether to discontinue nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Amitriptyline: Antidepressant with sedative effects; mechanism in humans not fully known. Inhibits the membrane pump responsible for neuronal uptake of norepinephrine and serotonin; not a monoamine oxidase inhibitor.