سعر الزاك 10مجم 20 كبسولة 2022

Fluoxetine 10 mg capsules, pack of 20 (2 strips); selective serotonin reuptake inhibitor antidepressant.

• Acute and maintenance treatment of major depressive disorder (adults and pediatric patients 8-18 years)Population: Adults and pediatric patients 8-18 yearsDailyMed (U.S. National Library of Medicine)
• Acute and maintenance treatment of obsessive-compulsive disorder (adults and pediatric patients 7-17 years)Population: Adults and pediatric patients 7-17 yearsDailyMed (U.S. National Library of Medicine)
• Acute and maintenance treatment of binge-eating and vomiting behaviors in moderate to severe bulimia nervosaPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (≥5% and at least twice placebo) across indications include abnormal dreams, abnormal ejaculation, anorexia, anxiety, asthenia, diarrhea, dry mouth, dyspepsia, flu syndrome, impotence, insomnia, decreased libido, nausea, nervousness, pharyngitis, rash, sinusitis, somnolence, sweating, tremor, vasodilatation and yawning.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Use with or within 14 days of stopping an MAOI intended to treat psychiatric disorders, or within 5 weeks of stopping fluoxetine before starting an MAOI; starting fluoxetine in patients treated with linezolid or intravenous methylene blue.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Use with pimozide or thioridazine.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients; closely monitor all antidepressant-treated patients for clinical worsening and emergence of suicidal thoughts and behaviors.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serotonin syndrome (with other serotonergic drugs); rash and allergic reactions; screen for bipolar disorder before starting (risk of mania/hypomania); seizures; altered appetite and weight.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Increased bleeding risk, especially with aspirin, NSAIDs, warfarin or other anticoagulants; angle-closure glaucoma; hyponatremia (especially in elderly); QT prolongation and ventricular arrhythmia; possible impairment of judgment and motor skills; long elimination half-life.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• MAOIs, linezolid, intravenous methylene blueContraindicatedContraindicated combinations because of the risk of serotonin syndrome (see contraindications).DailyMed (U.S. National Library of Medicine)
• Pimozide, thioridazineContraindicatedContraindicated: risk of QT prolongation.DailyMed (U.S. National Library of Medicine)
• Other serotonergic drugs (triptans, tricyclics, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John's Wort)Increased risk of serotonin syndrome; monitor.DailyMed (U.S. National Library of Medicine)

• Pregnancy: data from observational studies have not established an increased risk of major birth defects; SSRI exposure near delivery may increase the risk of postpartum hemorrhage (less than 2-fold); third-trimester exposure is associated with persistent pulmonary hypertension of the newborn and poor neonatal adaptation.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Fluoxetine is present in human milk; there are reports of agitation, irritability, poor feeding and poor weight gain in breastfed infants. Monitor breastfed infants for these effects.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fluoxetine: Exact mechanism unknown; presumed to be linked to inhibition of CNS neuronal uptake of serotonin (US label).