سعر ALENDOMAX PLUS 70MG/2800 I.U. 2 TABS. 2026

Alendomax Plus 70 mg/2800 IU, 2 tablets of alendronate with vitamin D3 (Sigma > Aspin Pharmaceutical, Egypt); once-weekly bisphosphonate plus vitamin D.

• Most common for alendronate (>=3%): abdominal pain, acid regurgitation, constipation, diarrhoea, dyspepsia, musculoskeletal pain, nausea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Oesophageal abnormalities delaying emptying (stricture, achalasia); inability to stand or sit upright for at least 30 minutes; hypocalcaemia; hypersensitivity to any component.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Upper GI adverse reactions; hypocalcaemia must be corrected before starting; severe musculoskeletal pain; osteonecrosis of the jaw; atypical femoral fractures; should not be used alone to treat vitamin D deficiency.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Calcium supplements, antacids, multivalent cationsInterfere with alendronate absorption; wait at least 30 minutes.DailyMed (U.S. National Library of Medicine)
• Aspirin / NSAIDsMay worsen upper GI irritation.DailyMed (U.S. National Library of Medicine)
• Drugs impairing vitamin D absorption or increasing its catabolismAdditional vitamin D supplementation should be considered.DailyMed (U.S. National Library of Medicine)

• Data in pregnant women are insufficient to inform a drug-associated risk; discontinue when pregnancy is recognised.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Cholecalciferol and some active metabolites pass into breast milk; unknown whether alendronate is present in human milk.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Alendronate (alendronic acid): Binds bone hydroxyapatite and inhibits osteoclast-mediated bone resorption (US FOSAMAX PLUS D label).
• Vitamin D3 (cholecalciferol): Fat-soluble vitamin converted in liver then kidney to active calcitriol; enhances intestinal calcium and phosphate absorption and supports bone mineralization.