سعر اميبروستون 24مكجم 20 كبسولة 2024

Lubiprostone 24 mcg capsules, pack of 20 (2 strips); chloride channel activator for chronic idiopathic and opioid-induced constipation.

• Chronic idiopathic constipation (CIC) in adultsPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Opioid-induced constipation (OIC) in adults with chronic non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent opioid dose escalation (effectiveness with diphenylheptane opioids such as methadone not established)Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions in CIC (>4%): nausea (29%), diarrhea (12%), headache (11%), abdominal pain (8%), abdominal distension (6%) and flatulence (6%).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known or suspected mechanical gastrointestinal obstruction.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Nausea (take with food); diarrhea - avoid in severe diarrhea and stop if severe diarrhea occurs; syncope and hypotension (postmarketing, mostly at 24 mcg twice daily, risk increased by diarrhea, vomiting or blood-pressure-lowering drugs); dyspnea, typically within 30-60 minutes of dosing; evaluate patients with symptoms suggesting bowel obstruction before starting.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Diphenylheptane opioids (e.g. methadone)May interfere with the efficacy of lubiprostone in opioid-induced constipation (dose-dependent reduction in efficacy observed).DailyMed (U.S. National Library of Medicine)

• Limited human data are insufficient to inform a drug-associated risk of major birth defects and miscarriage; fetal loss occurred in guinea pigs at doses about 0.2-6 times the human dose; weigh benefits and risks.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No data on presence in human milk or effects on milk production; monitor breastfed infants for diarrhea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Lubiprostone: Locally acting activator of ClC-2 chloride channels on the apical membrane of the intestinal epithelium, increasing chloride-rich intestinal fluid secretion and motility (US label).