سعر بينتاسيرين 50 مجم 30 كبسولة 2026

Diacerein 50 mg capsules, a slow-acting symptomatic treatment for osteoarthritis.

• Symptomatic treatment with delayed effect of hip and knee osteoarthritis (not recommended in rapidly progressive hip osteoarthritis)Population: Adults over 15 yearsBase de Données Publique des Médicaments (ANSM)

• Very common: diarrhoea, abdominal pain. Common: frequent stools, flatulence, pruritus, rash, eczema. Rare: raised liver enzymes. Also urine discoloration and colonic melanosis.International label, same formulation · Base de Données Publique des Médicaments (ANSM)

• Inflammatory bowel disease (ulcerative colitis, Crohn's), intestinal obstruction or sub-occlusion, abdominal pain of unknown cause, hypersensitivity to rhein or excipients, and current or past liver disease.International label, same formulation · Base de Données Publique des Médicaments (ANSM)

• Diarrhoea is common and may cause dehydration and hypokalaemia; stop treatment if diarrhoea occurs. Avoid laxatives.International label, same formulation · Base de Données Publique des Médicaments (ANSM)
• Hepatotoxicity: raised liver enzymes and acute liver injury reported; screen for liver disease, monitor for signs, limit alcohol, and stop if enzymes rise.International label, same formulation · Base de Données Publique des Médicaments (ANSM)

• Antacids / GI topical agents (Al, Ca, Mg salts)Reduce diacerein absorption; separate administration by more than 2 hours.Base de Données Publique des Médicaments (ANSM)
• Diuretics (loop, thiazide) and cardiac glycosides (digoxin, digitoxin)Diacerein-induced diarrhoea and hypokalaemia increase arrhythmia risk; use with particular caution.Base de Données Publique des Médicaments (ANSM)

• Not recommended in pregnancy: insufficient clinical data; delayed fetal ossification in animals at maternotoxic doses.International label, same formulation · Base de Données Publique des Médicaments (ANSM)
• Not recommended during breastfeeding; small amounts of anthraquinone derivatives pass into breast milk.International label, same formulation · Base de Données Publique des Médicaments (ANSM)

• Diacerein: Anthraquinone derivative fully deacetylated to rhein; in vitro inhibits interleukin-1 production, macrophage phagocytosis/migration and collagenolytic activity; onset slow (about day 30, significant by day 45).