سعر اسماتروبيم 500مكجم/مل 20 امبول 2024

Asmatropim 500 mcg/2 ml, box of 20 nebuliser vials (Global Advanced Pharmaceuticals (GAP) / Global Pharmaceutical Industries, Egypt): ipratropium bromide solution for inhalation by nebuliser, an anticholinergic bronchodilator.

• Treatment of reversible bronchospasm associated with chronic obstructive pulmonary disease (COPD).Population: Adults and childrenelectronic medicines compendium (emc), UK
• Used together with inhaled beta2-agonists for reversible airways obstruction as in acute and chronic asthma.Population: Adults and childrenelectronic medicines compendium (emc), UK

• Common: headache, dizziness, throat irritation, cough, dry mouth, nausea and gastro-intestinal motility disorders.International label, same formulation · electronic medicines compendium (emc), UK
• Uncommon: hypersensitivity/anaphylaxis, blurred vision, mydriasis, increased intra-ocular pressure, glaucoma, eye pain, palpitations, supraventricular tachycardia, bronchospasm, laryngospasm, vomiting, stomatitis, rash, pruritus and urinary retention; rare: atrial fibrillation, accommodation disorder, urticaria.International label, same formulation · electronic medicines compendium (emc), UK

• Known hypersensitivity to atropine or its derivatives (including ipratropium bromide) or to any other component of the product.International label, same formulation · electronic medicines compendium (emc), UK

• Use of the nebuliser solution should be closely supervised during initial dosing; immediate hypersensitivity reactions (urticaria, angioedema, rash, bronchospasm, oropharyngeal oedema, anaphylaxis) have occurred.International label, same formulation · electronic medicines compendium (emc), UK
• Paradoxical (inhalation-induced) bronchospasm may occur; treat immediately with a fast-acting inhaled bronchodilator, stop the product and reassess the patient.International label, same formulation · electronic medicines compendium (emc), UK
• Ocular complications (mydriasis, raised intra-ocular pressure, narrow-angle glaucoma, eye pain) have been reported when the nebulised mist entered the eyes; use caution in patients predisposed to narrow-angle glaucoma, protect the eyes and preferably use a mouthpiece.International label, same formulation · electronic medicines compendium (emc), UK

• Other anticholinergic drugsChronic co-administration with other anticholinergic drugs has not been studied and is not recommended.electronic medicines compendium (emc), UK
• Beta-adrenergic agonists and xanthine preparationsMay produce an additive bronchodilator effect; the risk of acute glaucoma in patients with a history of narrow-angle glaucoma may increase when nebulised ipratropium and beta2-agonists are given together.electronic medicines compendium (emc), UK
• Disodium cromoglycate nebuliser solutions containing benzalkonium chlorideShould not be given simultaneously in the same nebuliser because precipitation may occur.electronic medicines compendium (emc), UK

• Safety in human pregnancy has not been established; weigh the benefit against possible hazards to the unborn child. Nonclinical studies showed no embryotoxic or teratogenic effects after inhalation or intranasal use at doses well above human doses.International label, same formulation · electronic medicines compendium (emc), UK
• US label: animal reproduction studies showed no teratogenic effects, but there are no adequate well-controlled studies in pregnant women; use in pregnancy only if clearly needed.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• It is not known whether ipratropium bromide passes into breast milk; it is unlikely to reach the infant to an important extent, but caution is advised in nursing mothers.International label, same formulation · electronic medicines compendium (emc), UK

• Ipratropium bromide: Quaternary ammonium anticholinergic that antagonises acetylcholine at muscarinic receptors on bronchial smooth muscle, inhibiting vagally mediated bronchoconstriction; bronchodilation results from local drug concentrations in the airways rather than systemic levels.