سعر امريفيللين 300 مجم 5 اقماع لبوس 2023

Theophylline 300 mg rectal suppositories (Amriphylline, Amriya, Egypt), a methylxanthine bronchodilator; 5 suppositories per pack.

• Treatment of the symptoms and reversible airflow obstruction associated with chronic asthma and other chronic lung diseases (e.g. emphysema, chronic bronchitis) - US oral solution indication.Population: Adults and childrenDailyMed (U.S. National Library of Medicine)

• At peak serum concentrations <20 mcg/mL adverse effects are usually mild and caffeine-like (nausea, vomiting, headache, insomnia); above 20 mcg/mL persistent vomiting, cardiac arrhythmias and intractable seizures, which can be lethal, may occur.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to theophylline or other components of the product.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Use with extreme caution in active peptic ulcer disease, seizure disorders and cardiac arrhythmias (not including bradyarrhythmias).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Many factors reduce theophylline clearance (age extremes - neonates, infants <1 year, elderly >60 years; acute pulmonary oedema, congestive heart failure, fever, hepatic disease, hypothyroidism, sepsis; interacting drugs); if the dose is not reduced, severe and potentially fatal toxicity can occur.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• If nausea or vomiting (especially repetitive) or other signs of toxicity develop, withhold further doses and measure the serum theophylline concentration.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Drugs that inhibit theophylline metabolism (e.g. cimetidine, erythromycin, tacrine)Adding such a drug can raise theophylline levels and cause toxicity; monitor serum concentrations and adjust dose.DailyMed (U.S. National Library of Medicine)
• Drugs that enhance theophylline metabolism (e.g. carbamazepine, rifampin)Stopping such a drug can raise theophylline levels; starting it may reduce efficacy.DailyMed (U.S. National Library of Medicine)

• Older-format US label: no adequate and well-controlled studies in pregnant women; theophylline clearance may decrease in the third trimester.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Theophylline passes into breast milk at about the maternal serum concentration and may cause irritability or other signs of mild toxicity in nursing infants.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Theophylline: Relaxes airway smooth muscle (bronchodilation) and suppresses airway responsiveness to stimuli; bronchodilation is thought to be mediated by inhibition of phosphodiesterase isozymes PDE III and, to a lesser extent, PDE IV (US label; mechanisms not known with certainty).