سعر اتيموس 12 ميكرو 100 جرعة 2022

Formoterol fumarate 12 micrograms per actuation pressurised inhalation solution (metered-dose aerosol, 100 doses) by Chiesi (Italy), distributed in Egypt by Pharma Over Seas; a long-acting beta-2 agonist bronchodilator.

• Long-term symptomatic treatment of persistent, moderate to severe asthma in patients needing regular bronchodilator therapy with long-term inhaled and/or oral corticosteroidsPopulation: Adults and adolescents 12 years and olderelectronic medicines compendium (emc), UK
• Relief of broncho-obstructive symptoms in chronic obstructive pulmonary disease (COPD)Population: Adults 18 years and olderelectronic medicines compendium (emc), UK

• Common: tremor, headache, palpitations. Uncommon: hypokalaemia, hyperglycaemia, agitation, restlessness, sleep disorder, dizziness, taste disturbance, tachycardia. Rare: hypersensitivity reactions (angioedema, bronchospasm, exanthema, urticaria, pruritus). Very rare: thrombocytopenia, cardiac arrhythmias. Beta-2 agonist effects such as tremor and palpitations tend to be mild and subside within a few days.International label, same product · electronic medicines compendium (emc), UK

• Hypersensitivity to formoterol or to any of the excipients.International label, same product · electronic medicines compendium (emc), UK

• Not a first treatment for asthma and not for acute attacks; asthmatic patients on a LABA must also receive optimal maintenance inhaled corticosteroid therapy and should not stop or change their steroid therapy; do not start during an acute severe exacerbation.International label, same product · electronic medicines compendium (emc), UK
• Serious asthma-related adverse events and exacerbations may occur; exceeding the prescribed or maximum daily dose is hazardous (cardiac arrhythmia, raised blood pressure, electrolyte shifts).International label, same product · electronic medicines compendium (emc), UK
• Use with caution in severe cardiovascular disease (e.g. third-degree AV block, ischaemic heart disease, tachyarrhythmias, severe heart failure, hypertrophic obstructive cardiomyopathy, severe hypertension, aneurysm), thyrotoxicosis, phaeochromocytoma, refractory diabetes and QTc prolongation; monitor blood glucose initially in diabetics.International label, same product · electronic medicines compendium (emc), UK

• Beta-adrenergic blockers (including eye drops)May weaken or inhibit the effect of formoterol; avoid co-administration unless there are compelling reasons.electronic medicines compendium (emc), UK
• QTc-prolonging drugs (e.g. quinidine, disopyramide, procainamide, erythromycin, tricyclic antidepressants, some antihistamines), MAO inhibitorsTheoretical increased risk of ventricular arrhythmias / potentiated cardiovascular effects; use with caution.electronic medicines compendium (emc), UK
• Xanthine derivatives (e.g. theophylline), corticosteroids, thiazide and loop diuretics; digitalis glycosidesMay potentiate beta-2 agonist hypokalaemia, increasing arrhythmia risk in patients on digitalis.electronic medicines compendium (emc), UK

• No or limited data in pregnant women; animal studies showed implantation losses and reduced early postnatal survival and birth weight at exposures well above clinical levels. Formoterol may be considered at all stages of pregnancy if needed for asthma control and the expected benefit outweighs any possible fetal risk.International label, same product · electronic medicines compendium (emc), UK
• Unknown whether formoterol is excreted in human milk (small amounts found in rat milk); use during breastfeeding only if the expected benefit to the mother outweighs any possible risk to the child.International label, same product · electronic medicines compendium (emc), UK

• Formoterol fumarate dihydrate: Predominantly selective beta-2 adrenoceptor agonist; bronchodilation begins within 1-3 minutes and is still significant 12 hours after inhalation (UK Atimos Modulite SmPC).