سعر اوجرام 642.9مجم/5مل معلق 60 مل 2024

Amoxicillin 600 mg + clavulanic acid 42.9 mg per 5 ml powder for oral suspension (Augram 642.9 mg/5 ml, 14:1 extra-strength paediatric formulation), 60 ml bottle, by Rameda (Egypt).

• Recurrent or persistent acute otitis media due to S. pneumoniae (penicillin MIC 2 mcg/mL or less), H. influenzae or M. catarrhalis (including beta-lactamase producers) in children with risk factors (antibiotic exposure for otitis media within 3 months and age 2 years or younger or day-care attendance).Population: Children 3 months to 12 years weighing 40 kg or lessDailyMed (U.S. National Library of Medicine)
• Acute bacterial sinusitis in children 3 months to 12 years (paediatric-use statement of the label).Population: Children 3 months to 12 yearsDailyMed (U.S. National Library of Medicine)

• In paediatric acute otitis media trials (90/6.4 mg/kg/day for 10 days): vomiting (7%), fever (6%), diaper rash (6%), upper respiratory tract infection (4%) and diarrhoea (4%); protocol-defined diarrhoea in 13%.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to amoxicillin, clavulanate or other beta-lactam antibacterials (penicillins, cephalosporins).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Previous history of cholestatic jaundice/hepatic dysfunction associated with amoxicillin and clavulanate potassium.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Serious allergic reactions including anaphylaxis, severe cutaneous adverse reactions (SJS, TEN, DRESS, AGEP), drug-induced enterocolitis syndrome, hepatic dysfunction, Clostridioides difficile-associated diarrhoea, rash in mononucleosis and microbial overgrowth are labelled warnings.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Contains aspartame (a phenylalanine source): 7 mg phenylalanine per 5 mL in the US product; relevant for phenylketonurics.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• ProbenecidIncreases and prolongs amoxicillin blood levels; co-administration is not recommended.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulantsIncreased prothrombin time/INR reported; monitor and adjust the anticoagulant dose if needed.DailyMed (U.S. National Library of Medicine)
• AllopurinolIncreased incidence of rash with concurrent use.DailyMed (U.S. National Library of Medicine)

• Published epidemiologic data and pharmacovigilance reports over decades have not established a drug-associated risk of major birth defects, miscarriage or adverse maternal outcomes; animal studies showed no fetal harm.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Amoxicillin is present in human milk; diarrhoea, irritability and rash have been reported in breastfed infants, who should be monitored.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Amoxicillin: Bactericidal beta-lactam that inhibits bacterial cell-wall synthesis; inactivated by beta-lactamases.
• Clavulanic acid: Beta-lactam that inactivates some beta-lactamases, protecting amoxicillin from degradation.