سعر بيبي ريليف 12.5 مجم 5 اقماع 2025

Diclofenac sodium 12.5 mg rectal suppositories, pack of 5; non-steroidal anti-inflammatory drug (Pharo Pharma, Egypt).

• Juvenile chronic arthritisPopulation: Children aged 1-12 yearselectronic medicines compendium (eMC)
• Acute post-operative pain (monotherapy or adjunct to opioids)Population: Children aged 6 years and aboveelectronic medicines compendium (eMC)

• Common: headache, dizziness, vertigo, nausea, vomiting, diarrhoea, dyspepsia, abdominal pain, flatulence, anorexia, increased transaminases, rash.International label, same formulation · electronic medicines compendium (eMC)
• Rare or very rare: gastrointestinal haemorrhage or ulcer, hepatitis, hypersensitivity/anaphylaxis, asthma, blood dyscrasias, severe bullous skin reactions, acute renal failure; application-site irritation (rare).International label, same formulation · electronic medicines compendium (eMC)

• Hypersensitivity to diclofenac or any excipient; patients in whom asthma, angioedema, urticaria or acute rhinitis are precipitated by ibuprofen, acetylsalicylic acid or other NSAIDs.International label, same formulation · electronic medicines compendium (eMC)
• Active gastric or intestinal ulcer, bleeding or perforation; history of gastrointestinal bleeding or perforation related to previous NSAID therapy; active or history of recurrent peptic ulcer/haemorrhage.International label, same formulation · electronic medicines compendium (eMC)
• Hepatic failure; renal failure; established congestive heart failure (NYHA II-IV), ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease.International label, same formulation · electronic medicines compendium (eMC)

• Gastrointestinal bleeding, ulceration or perforation, sometimes fatal, can occur at any time; risk rises with dose and in patients with ulcer history or the elderly. Use the lowest effective dose and caution in ulcerative colitis or Crohn's disease; stop if GI bleeding occurs.International label, same formulation · electronic medicines compendium (eMC)
• Increased risk of arterial thrombotic events (myocardial infarction, stroke), particularly at high doses (150 mg/day) and with long-term use; treat patients with cardiovascular risk factors only after careful consideration.International label, same formulation · electronic medicines compendium (eMC)
• Serious skin reactions (exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) have been reported very rarely, mostly in the first month; discontinue at the first sign of rash, mucosal lesions or hypersensitivity.International label, same formulation · electronic medicines compendium (eMC)

• LithiumMay increase plasma lithium concentrations; monitor serum lithium.electronic medicines compendium (eMC)
• Digoxin and cardiac glycosidesMay raise plasma digoxin levels and exacerbate cardiac failure; monitor digoxin levels.electronic medicines compendium (eMC)
• Diuretics and antihypertensives (ACE inhibitors, beta-blockers)Reduced antihypertensive effect and increased nephrotoxicity risk; monitor blood pressure and renal function and keep patients hydrated.electronic medicines compendium (eMC)

• Inhibition of prostaglandin synthesis may adversely affect pregnancy; epidemiological data suggest an increased risk of miscarriage, cardiac malformation and gastroschisis after use in early pregnancy, increasing with dose and duration.International label, same formulation · electronic medicines compendium (eMC)
• Diclofenac passes into breast milk in small amounts; it should not be administered during breastfeeding.International label, same formulation · electronic medicines compendium (eMC)

• Diclofenac sodium: Inhibits prostaglandin synthetase (cyclo-oxygenase), reducing prostaglandin synthesis and thereby pain, inflammation and fever.