سعر باكتيزوليد 100 مجم /5 مل معلق 150 مل 2022

Linezolid 100 mg/5 mL oral suspension (Bactizolid, Eva Pharma, Egypt), 150 mL bottle. Oxazolidinone antibacterial.

• Nosocomial pneumonia caused by Staphylococcus aureus (methicillin-susceptible and -resistant) or Streptococcus pneumoniae.Population: Adults and childrenDailyMed (U.S. National Library of Medicine)
• Community-acquired pneumonia caused by Streptococcus pneumoniae (including concurrent bacteraemia) or methicillin-susceptible Staphylococcus aureus.Population: Adults and childrenDailyMed (U.S. National Library of Medicine)
• Complicated skin and skin-structure infections, including diabetic foot infections without concomitant osteomyelitis, caused by S. aureus (MSSA/MRSA), Streptococcus pyogenes or Streptococcus agalactiae.Population: Adults and childrenDailyMed (U.S. National Library of Medicine)

• Adults (Phase 3 trials, 600 mg every 12 hours): diarrhoea 8.3%, nausea 6.6%, headache 5.7%, vomiting 4.3%, rash 2.3%, anaemia 2.1%, dizziness 1.8%, oral moniliasis 1.7%, abnormal liver function tests 1.6%; also taste alteration, vaginal moniliasis, tongue discolouration and abdominal pain.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Children (birth to 11 years): diarrhoea, vomiting, anaemia and thrombocytopenia were among the most frequent; thrombocytopenia appears related to duration of therapy (generally more than 2 weeks).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Postmarketing: anaphylaxis, angioedema, severe cutaneous adverse reactions (TEN, SJS), hypersensitivity vasculitis, myelosuppression and sideroblastic anaemia, peripheral/optic neuropathy, serotonin syndrome, lactic acidosis, convulsions, rhabdomyolysis, hypoglycaemia, hyponatraemia/SIADH, and superficial tooth and tongue discolouration.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to linezolid or any other product component.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Patients taking any medicinal product that inhibits monoamine oxidase A or B (e.g. phenelzine, isocarboxazid) or within two weeks of taking such a product.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Myelosuppression (anaemia, leukopenia, pancytopenia, thrombocytopenia) has been reported; monitor complete blood counts weekly, especially with therapy longer than 2 weeks, pre-existing myelosuppression, severe renal or moderate-severe hepatic impairment or myelosuppressive co-medication; consider discontinuation if it develops or worsens.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Peripheral and optic neuropathy, mainly with treatment beyond the maximum 28 days (optic neuropathy may progress to loss of vision); prompt ophthalmic evaluation for visual symptoms and monitoring of visual function with therapy of 3 months or longer.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serotonin syndrome, including fatal cases, with concomitant serotonergic agents (SSRIs, SNRIs, tricyclic antidepressants, buspirone, triptans, opioids including meperidine) or carcinoid syndrome; monitor and discontinue as appropriate.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• MAO inhibitors (e.g. phenelzine, isocarboxazid)Linezolid is a reversible nonselective MAO inhibitor; contraindicated with MAO-A/B inhibitors or within 2 weeks of them.DailyMed (U.S. National Library of Medicine)
• Serotonergic agents (SSRIs, SNRIs, tricyclics, buspirone, triptans, opioids incl. meperidine)Risk of serotonin syndrome, including fatal cases; monitor and consider discontinuation.DailyMed (U.S. National Library of Medicine)
• Adrenergic agents (pseudoephedrine, phenylpropanolamine, epinephrine, norepinephrine, dopamine, dobutamine)Pressor response: mean maximum systolic rise of 32-38 mm Hg with pseudoephedrine or phenylpropanolamine; monitor blood pressure or avoid.DailyMed (U.S. National Library of Medicine)

• Available data from published and postmarketing case reports have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; no malformations in animal studies, but embryo-fetal lethality in mice at 6.5 times human exposure and decreased pup survival in rats at about human exposure.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Linezolid is present in breast milk; the infant dose from milk is estimated at about 6-9% of the recommended infant therapeutic dose. Consider the benefits of breastfeeding and the mother's need for linezolid, and monitor the breastfed infant for diarrhoea and vomiting.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Linezolid: Binds to the 23S ribosomal RNA of the bacterial 50S subunit and prevents formation of a functional 70S initiation complex, inhibiting bacterial protein synthesis.