سعر بيوريفامين biorefamin‏ 200مجم 20 قرص 2026

Biorefamin rifaximin 200 mg film-coated tablets, pack of 20 (SoValue Pharma, Egypt).

• Most common: travelers' diarrhea (>=2%) headache; hepatic encephalopathy (>=10%) peripheral edema, nausea, constipation, dizziness, fatigue, urinary tract infection, insomnia, anemia, pruritus and ascites; IBS-D (>=2%) ALT increased and nausea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to rifaximin, any rifamycin antimicrobial agent or any component; reactions have included exfoliative dermatitis, angioneurotic edema and anaphylaxis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Not effective in travelers' diarrhea complicated by fever and/or blood in the stool or caused by pathogens other than E. coli; discontinue if symptoms worsen or persist beyond 24-48 hours.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhea has been reported; evaluate if diarrhea occurs after or worsens during therapy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Caution with concomitant P-glycoprotein inhibitors (e.g. cyclosporine), which significantly increase systemic exposure.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• WarfarinChanges in INR reported; monitor INR and prothrombin time; warfarin dose adjustment may be needed.DailyMed (U.S. National Library of Medicine)
• P-glycoprotein inhibitors (e.g. cyclosporine)Cyclosporine significantly increased systemic exposure to rifaximin; use with caution.DailyMed (U.S. National Library of Medicine)

• No available human data; teratogenic effects (ocular, oral/maxillofacial, cardiac, lumbar spine malformations) were seen in rats and rabbits; advise pregnant women of potential fetal risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on presence in human milk or effects on the breastfed infant or milk production; weigh benefits of breastfeeding against maternal need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Rifaximin: Binds bacterial DNA-dependent RNA polymerase beta-subunit, inhibiting transcription and bacterial protein synthesis; minimal systemic absorption after oral dosing.