سعر نو ديبرين 50مجم 30 قرص 2023

No Deprine 50 mg tofisopam tablets (Alfacure Pharmaceuticals, Egypt), box of 30; anxiolytic.

• Neurotic and somatic disorders associated with anxiety, autonomic disturbances, lack of energy and/or motivation, apathy, fatigue, depressed moodPopulation: AdultsZāļu valsts aģentūra (State Agency of Medicines of Latvia)
• Alcohol withdrawal syndrome: treatment of autonomic symptoms in the pre-delirium and delirium phasePopulation: AdultsZāļu valsts aģentūra (State Agency of Medicines of Latvia)

• Frequency not known, usually mild and transient, mostly at high doses: headache, tension, insomnia, irritability, agitation, confusion, seizures in epileptics; respiratory depression; decreased appetite, constipation, flatulence, nausea, dry mouth, cholestatic jaundice; rash, pruritus; muscle tension and pain.International label, equivalent formulation · Zāļu valsts aģentūra (State Agency of Medicines of Latvia)

• Hypersensitivity to tofisopam, excipients or other benzodiazepine derivatives; decompensated respiratory failure; history of sleep apnoea syndrome; history of coma; chronic psychoses, phobias or obsessive-compulsive states; severe hepatic failure; concomitant tacrolimus, sirolimus or ciclosporin; first trimester of pregnancy; breastfeeding; children under 18 years.International label, equivalent formulation · Zāļu valsts aģentūra (State Agency of Medicines of Latvia)

• Caution with history of acute respiratory failure, in the elderly, mentally ill and patients with hepatic and/or renal impairment; concomitant opioids may cause sedation, respiratory depression, coma and death; not recommended as monotherapy for depression; may provoke seizures in epilepsy; not recommended in angle-closure glaucoma; dependence and withdrawal symptoms possible (taper gradually); paradoxical reactions; avoid alcohol; contains lactose (Grandaxin).International label, equivalent formulation · Zāļu valsts aģentūra (State Agency of Medicines of Latvia)

• OpioidsConcomitant use may cause sedation, respiratory depression, coma and death; limit dose and duration.Zāļu valsts aģentūra (State Agency of Medicines of Latvia)
• CNS depressants (analgesics, general anaesthetics, antidepressants, H1 antihistamines, sedatives/hypnotics, antipsychotics)Effects of either drug may be enhanced.Zāļu valsts aģentūra (State Agency of Medicines of Latvia)
• Tacrolimus, sirolimus, ciclosporinConcomitant use is contraindicated.Zāļu valsts aģentūra (State Agency of Medicines of Latvia)

• Tofisopam crosses the placenta; use in later pregnancy only after careful benefit-risk assessment.International label, equivalent formulation · Zāļu valsts aģentūra (State Agency of Medicines of Latvia)
• Tofisopam is excreted in breast milk; must not be used during breastfeeding.International label, equivalent formulation · Zāļu valsts aģentūra (State Agency of Medicines of Latvia)

• Tofisopam: Short-acting, weak anxiolytic with a wide therapeutic index; its precise mechanism is poorly known and it differs from classical 1,4-benzodiazepines in structure and pharmacology (Latvian Grandaxin SmPC 5.1).