سعر سيبروسين Ciprocin‏ 500مجم 10 اقراص 2026

Ciprocin 500 mg 10 film-coated tablets (Ciprofloxacin (as hydrochloride)), film-coated tablet, by EIPICO (Egyptian International Pharmaceutical Industries Co.).

• Most frequent adverse reactions in clinical trials: nausea (2.5%), diarrhoea (1.6%), abnormal liver function tests (1.3%), vomiting (1%) and rash (1%).International label, same formulation · DailyMed (US National Library of Medicine)
• Postmarketing: QT prolongation/torsade de pointes, peripheral neuropathy, tendinitis/tendon rupture, hepatic failure, pseudomembranous colitis, pancytopenia, psychiatric reactions (agitation, confusion, delirium) and severe skin reactions (e.g. AGEP).International label, same formulation · DailyMed (US National Library of Medicine)

• Hypersensitivity to ciprofloxacin, any other quinolone or any product component.International label, same formulation · DailyMed (US National Library of Medicine)
• Concomitant use with tizanidine.International label, same formulation · DailyMed (US National Library of Medicine)

• Boxed warning: fluoroquinolones are associated with disabling and potentially irreversible serious reactions (tendinitis and tendon rupture, peripheral neuropathy, CNS effects) and may exacerbate myasthenia gravis; avoid in patients with known myasthenia gravis; reserve for patients without alternatives in acute bacterial sinusitis, acute exacerbation of chronic bronchitis and uncomplicated UTI.International label, same formulation · DailyMed (US National Library of Medicine)
• Risk of aortic aneurysm and dissection; avoid in patients with known aneurysm or at risk unless no alternative.International label, same formulation · DailyMed (US National Library of Medicine)
• QT prolongation and torsade de pointes; avoid with QT-prolonging drugs and in patients with risk factors.International label, same formulation · DailyMed (US National Library of Medicine)

• TizanidineContraindicated: large increase in tizanidine exposure (hypotension, sedation).DailyMed (US National Library of Medicine)
• TheophyllineRaised theophylline levels with serious and fatal reactions; monitor levels and adjust dose.DailyMed (US National Library of Medicine)
• Multivalent cation products (antacids, sucralfate, iron, zinc, calcium)Markedly reduced ciprofloxacin absorption; separate dosing (2 h before or 6 h after).DailyMed (US National Library of Medicine)

• Decades of published experience have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal/fetal outcomes; animal studies showed no malformations.International label, same formulation · DailyMed (US National Library of Medicine)
• Ciprofloxacin is present in human milk; because of potential serious adverse reactions (arthropathy) in the infant, pump and discard or avoid breastfeeding during treatment and for 2 days after the last dose (except anthrax post-exposure risk-benefit).International label, same formulation · DailyMed (US National Library of Medicine)

• Ciprofloxacin (as hydrochloride): Bactericidal fluoroquinolone that inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, blocking DNA replication.