سعر ابيكوفلوسين 200 مجم 10 قرص 2025

Epicoflocin 200 mg 10 f.c.tab.: ofloxacin 200 mg film-coated tablets (EIPICO, Egypt).

• Uncomplicated acute cystitis (only when other commonly recommended antibacterial agents are considered inappropriate); acute pyelonephritis; complicated urinary tract infections; acute exacerbations of chronic obstructive pulmonary disease including chronic bronchitis; community-acquired pneumonia (only when other commonly recommended agents are inappropriate); gonococcal urethritis and cervicitis due to susceptible Neisseria gonorrhoeae, and non-gonococcal urethritis and cervicitis (EIPICO product page).Population: AdultsEIPICO (Egyptian International Pharmaceutical Industries Co.)
• US label: reserve ofloxacin for patients with no alternative treatment options for acute exacerbation of chronic bronchitis and uncomplicated cystitis, because of serious fluoroquinolone adverse reactions (US label).Population: Adults ≥18 yearsDailyMed (U.S. National Library of Medicine)

• In clinical trials, drug-related adverse reactions with multiple doses included nausea (3%), insomnia (3%), headache, dizziness, diarrhea, vomiting, rash and pruritus (1% each); overall incidence of drug-related reactions was 11% (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to ofloxacin or other quinolones (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: fluoroquinolones including ofloxacin are associated with disabling and potentially irreversible serious adverse reactions — tendinitis and tendon rupture, peripheral neuropathy and central nervous system effects — and may exacerbate muscle weakness in myasthenia gravis; avoid in patients with known myasthenia gravis (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Tendon rupture risk is increased in patients over 60 years, those taking corticosteroids, and kidney, heart or lung transplant recipients; it can occur within hours or days of starting treatment or months after completion (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• QT prolongation and rare torsade de pointes have been reported; avoid in patients with known QT prolongation, uncorrected hypokalemia, or receiving class IA (quinidine, procainamide) or class III (amiodarone, sotalol) antiarrhythmics (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Antacids (calcium, magnesium, aluminum), sucralfate, iron, zinc-containing multivitamins, didanosineMajorShould not be taken within the two-hour period before or within the two-hour period after ofloxacin, as they reduce its absorption (US label).DailyMed (U.S. National Library of Medicine)
• TheophyllineModerateTheophylline levels may increase; monitor theophylline levels and adjust dose (US label).DailyMed (U.S. National Library of Medicine)
• WarfarinModerateMay enhance the effects of warfarin; monitor prothrombin time/INR (US label).DailyMed (U.S. National Library of Medicine)

• No teratogenic effects were seen in rats and rabbits at high oral doses; there are no adequate and well-controlled studies in pregnant women — use during pregnancy only if the potential benefit justifies the potential risk to the fetus (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• After a single 200 mg dose, ofloxacin concentrations in milk were similar to plasma; because of potential serious adverse reactions in nursing infants, decide whether to discontinue nursing or the drug (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

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