سعر كريستور 5 مجم 7 أقراص مغلفة 2024

Crestor 5 mg film-coated tablets, 7-tablet pack (rosuvastatin); AstraZeneca / IPR.

• Adjunct to diet and exercise to reduce LDL-C in adults with primary hypercholesterolemia.Population: AdultsDailyMed / FDA
• Reduce risk of major adverse cardiovascular events in adults at increased CV risk.Population: Adults at increased CV riskDailyMed / FDA

• Most frequent adverse reactions (≥2%): headache, nausea, myalgia, asthenia, constipation.International label, same product · DailyMed / FDA

• Contraindicated in acute liver failure or decompensated cirrhosis, and in hypersensitivity to rosuvastatin or any CRESTOR excipient.International label, same product · DailyMed / FDA

• Risk of myopathy and rhabdomyolysis (higher with age ≥65, uncontrolled hypothyroidism, renal impairment, interacting drugs, Asian ancestry, higher doses). Discontinue if marked CK elevation or myopathy suspected.International label, same product · DailyMed / FDA

• CyclosporineMajorDo not exceed Crestor 5 mg once daily with cyclosporine (≈7-fold increase in rosuvastatin exposure).DailyMed / FDA
• GemfibrozilMajorAvoid concomitant use; if unavoidable initiate 5 mg and do not exceed 10 mg once daily.DailyMed / FDA
• WarfarinModerateObtain INR before starting Crestor; monitor INR frequently until stable after initiation, titration or discontinuation.DailyMed / FDA

• Discontinue when pregnancy is recognized. May cause fetal harm based on HMG-CoA reductase inhibition. Breastfeeding not recommended during treatment.International label, same product · DailyMed / FDA
• Rosuvastatin is present in human milk; breastfeeding not recommended during CRESTOR treatment.International label, same product · DailyMed / FDA

• Rosuvastatin: Competitive inhibition of HMG-CoA reductase reduces hepatic cholesterol synthesis and increases LDL-receptor expression.