سعر ازيميب 10/20 مجم 10 اقراص 2022

Ezetimibe 10 mg + atorvastatin 20 mg film-coated tablets, 10 tablets; lipid-lowering combination (Innovision Pharm, Egypt).

• Adjunct to diet to reduce elevated total-C, LDL-C, Apo B, TG and non-HDL-C and to increase HDL-C in primary (heterozygous familial and non-familial) hyperlipidemia or mixed hyperlipidemiaPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Reduce total-C and LDL-C in homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments or if such treatments are unavailablePopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (incidence of 2% or more and greater than placebo): increased ALT, increased AST and musculoskeletal pain.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Active liver disease or unexplained persistent elevations in hepatic transaminase levels; hypersensitivity to any component; women who are pregnant or may become pregnant; nursing mothers.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy/rhabdomyolysis: risk increases with higher atorvastatin doses and with certain interacting drugs; predisposing factors include age over 65, uncontrolled hypothyroidism and renal impairment. Discontinue if markedly elevated CK or myopathy is diagnosed or suspected. Immune-mediated necrotizing myopathy has been reported with statins.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Liver enzyme abnormalities: perform liver enzyme tests before starting therapy and as clinically indicated; interrupt therapy if serious liver injury with clinical symptoms and/or hyperbilirubinemia or jaundice occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Limitation of use: no incremental benefit of the combination on cardiovascular morbidity and mortality over that of atorvastatin alone has been established.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Cyclosporine, tipranavir + ritonavir, telaprevir, gemfibrozilIncrease the risk of myopathy/rhabdomyolysis; avoid the combination.DailyMed (U.S. National Library of Medicine)
• Clarithromycin, itraconazole, HIV protease inhibitors (saquinavir, darunavir, fosamprenavir with or without ritonavir), elbasvir/grazoprevirRaise atorvastatin exposure; do not exceed 10/20 mg daily. Use lopinavir + ritonavir with caution at the lowest necessary dose.DailyMed (U.S. National Library of Medicine)
• Nelfinavir, boceprevirRaise atorvastatin exposure; do not exceed 10/40 mg daily.DailyMed (U.S. National Library of Medicine)

• Contraindicated in women who are pregnant or may become pregnant: atorvastatin may cause fetal harm; if pregnancy occurs during therapy, discontinue and inform the patient of the potential hazard to the fetus.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Contraindicated in nursing mothers; women taking the combination should not breastfeed.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Ezetimibe: Inhibits intestinal absorption of cholesterol and related phytosterols (US Vytorin label).
• Atorvastatin: Inhibits HMG-CoA reductase, reducing hepatic cholesterol synthesis.