سعر ازيتاسين 10/10 مجم 10 اقراص 2022

Ezetimibe 10 mg + simvastatin 10 mg film-coated tablets, 10 tablets; lipid-lowering combination (Mepaco, Egypt).

• Adjunct to diet to reduce LDL-C in adults with primary hyperlipidemiaPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Adjunct to diet to reduce LDL-C in adults and children aged 10 years and older with heterozygous familial hypercholesterolemiaPopulation: Adults and children 10 years and olderDailyMed (U.S. National Library of Medicine)
• Adjunct to other LDL-C-lowering therapies to reduce LDL-C in adults with homozygous familial hypercholesterolemiaPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions: headache, increased ALT, myalgia, upper respiratory tract infection and diarrhea.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant strong CYP3A4 inhibitors, cyclosporine, danazol or gemfibrozil; acute liver failure or decompensated cirrhosis; hypersensitivity to ezetimibe, simvastatin or any excipient.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis: risk factors include age 65 or older, uncontrolled hypothyroidism, renal impairment, higher simvastatin dose (especially 10/80 mg), certain interacting drugs, and Chinese patients; discontinue if markedly elevated CK or myopathy is diagnosed or suspected. Immune-mediated necrotizing myopathy has been reported.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hepatic dysfunction: increases in serum transaminases have occurred; consider liver enzyme testing before starting and when clinically indicated; if serious hepatic injury with clinical symptoms and/or hyperbilirubinemia or jaundice occurs, discontinue.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors (e.g. itraconazole, ketoconazole, clarithromycin, HIV protease inhibitors), cyclosporine, danazol, gemfibrozilGreatly increase the risk of myopathy/rhabdomyolysis; concomitant use is contraindicated.DailyMed (U.S. National Library of Medicine)
• Verapamil, diltiazem, dronedaroneIncrease simvastatin exposure; do not exceed 10/10 mg daily.DailyMed (U.S. National Library of Medicine)
• Amiodarone, amlodipine, ranolazineIncrease simvastatin exposure; do not exceed 10/20 mg daily.DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognized. Simvastatin decreases cholesterol synthesis and may cause fetal harm by its mechanism of action; available observational data have not shown a clear association with major congenital malformations. Consider ongoing therapeutic needs of the individual patient.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment (risk of serious adverse reactions in the breastfed infant).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Ezetimibe: Inhibits intestinal absorption of cholesterol and related phytosterols (US Vytorin label).
• Simvastatin: Inhibits HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis (US Vytorin label).