سعر كيورام 625مجم 12 قرص 2024

Curam (Sandoz) amoxicillin with clavulanic acid; Egyptian pack 12 film-coated tablets.

• Lower respiratory tract infections due to beta-lactamase–producing H. influenzae and M. catarrhalis (US label).Population: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Acute bacterial otitis media due to beta-lactamase–producing H. influenzae and M. catarrhalis (US label).Population: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Sinusitis due to beta-lactamase–producing H. influenzae and M. catarrhalis (US label).Population: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)

• Most frequent adverse effects: diarrhea/loose stools (9%), nausea (3%), skin rashes and urticaria (3%), vomiting (1%) and vaginitis (1%) (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Contraindicated with history of serious hypersensitivity (e.g. anaphylaxis or SJS) to amoxicillin, clavulanate or other beta-lactams, and with history of cholestatic jaundice/hepatic dysfunction associated with amox/clav (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Serious hypersensitivity; SCAR (SJS/TEN/DRESS/AGEP); drug-induced enterocolitis syndrome (DIES); hepatic dysfunction/cholestatic jaundice; Clostridioides difficile–associated diarrhea; rash in mononucleosis; possible superinfection (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• ProbenecidModerateProbenecid decreases renal tubular secretion of amoxicillin; co-administration not recommended (US label).DailyMed (U.S. National Library of Medicine)
• Oral anticoagulantsModerateMay prolong prothrombin time/INR; monitor and adjust anticoagulant dose if needed (US label).DailyMed (U.S. National Library of Medicine)
• AllopurinolModerateConcurrent allopurinol increases incidence of rashes with amoxicillin (US label).DailyMed (U.S. National Library of Medicine)

• Pregnancy Category B historical framing on US label: animal studies revealed no evidence of fetal harm; no adequate well-controlled studies in pregnant women; use during pregnancy only if clearly needed (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Amoxicillin is excreted in human milk; use by nursing mothers may lead to sensitization of infants; exercise caution (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Amoxicillin: Bactericidal beta-lactam that inhibits bacterial cell-wall biosynthesis during active multiplication; inactivated by beta-lactamases (US label, section 12.4).
• Clavulanic acid: Beta-lactam that inactivates some beta-lactamases, protecting amoxicillin from degradation.