سعر اوجرام 312.5مجم 10 قرص مضغ 2022

Amoxicillin 250 mg + clavulanic acid 62.5 mg chewable tablets (Augram 312.5 mg), pack of 10, by Rameda (Egypt); broad-spectrum penicillin/beta-lactamase-inhibitor antibiotic.

• Infections due to susceptible beta-lactamase-producing isolates: lower respiratory tract infections, acute bacterial otitis media, sinusitis, skin and skin-structure infections, urinary tract infections.Population: Adults and paediatric patientsDailyMed (U.S. National Library of Medicine)

• Most frequent: diarrhoea/loose stools (9%), nausea (3%), skin rashes and urticaria (3%), vomiting (1%) and vaginitis (1%); incidence, especially of diarrhoea, increases with higher doses.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Postmarketing: indigestion, gastritis, stomatitis, black hairy tongue, mucocutaneous candidiasis, pseudomembranous colitis, anaphylaxis, angioedema, serum sickness-like reactions, erythema multiforme, SJS/TEN, hepatitis and cholestatic jaundice.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• History of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to amoxicillin, clavulanate or other beta-lactam antibacterials (penicillins, cephalosporins).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Previous history of cholestatic jaundice/hepatic dysfunction associated with amoxicillin/clavulanate potassium.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Serious and occasionally fatal hypersensitivity (anaphylactic) reactions; ask about previous penicillin, cephalosporin or other allergies before starting and stop the drug if an allergic reaction occurs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Severe cutaneous adverse reactions (SJS, TEN, DRESS, AGEP) may occur; monitor skin rash closely and discontinue if lesions progress.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Drug-induced enterocolitis syndrome (protracted vomiting 1-4 hours after ingestion), mostly in children; discontinue if it occurs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• ProbenecidDecreases renal tubular secretion of amoxicillin, giving increased and prolonged amoxicillin levels; co-administration is not recommended.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulantsAbnormal prolongation of prothrombin time (increased INR) reported; monitor and adjust the anticoagulant dose if needed.DailyMed (U.S. National Library of Medicine)
• AllopurinolConcurrent use increases the incidence of rash compared with amoxicillin alone.DailyMed (U.S. National Library of Medicine)

• Animal reproduction studies (rats, mice) showed no fetal harm, but there are no adequate and well-controlled studies in pregnant women; use in pregnancy only if clearly needed.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Amoxicillin is excreted in human milk; use by nursing mothers may lead to sensitisation of infants, so caution is advised.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Amoxicillin: Bactericidal beta-lactam that inhibits bacterial cell-wall synthesis; inactivated by beta-lactamases.
• Clavulanic acid: Beta-lactam that inactivates some beta-lactamases, protecting amoxicillin from degradation.