سعر اوجرام 228.5مجم 10 قرص مضغ 2022

Augram 228.5 mg (amoxicillin 200 mg + clavulanic acid 28.5 mg) chewable tablets, pack of 10; penicillin with beta-lactamase inhibitor.

• Lower respiratory tract infections caused by beta-lactamase-producing isolates of Haemophilus influenzae and Moraxella catarrhalisPopulation: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Acute bacterial otitis media caused by beta-lactamase-producing isolates of H. influenzae and M. catarrhalisPopulation: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Sinusitis caused by beta-lactamase-producing isolates of H. influenzae and M. catarrhalisPopulation: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)

• Most frequently reported adverse reactions: diarrhea/loose stools (9%), nausea (3%), skin rashes and urticaria (3%), vomiting (1%) and vaginitis (1%); incidence, particularly of diarrhea, increases with higher doses.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Postmarketing: indigestion, gastritis, stomatitis, glossitis, DIES, black hairy tongue, mucocutaneous candidiasis, hemorrhagic/pseudomembranous colitis; anaphylaxis, angioedema, serum sickness-like reactions, hypersensitivity vasculitis; severe skin reactions; hepatitis and cholestatic jaundice; interstitial nephritis, crystalluria; blood dyscrasias; CNS effects including convulsions; tooth discoloration.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to amoxicillin, clavulanate or other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Previous history of cholestatic jaundice/hepatic dysfunction associated with amoxicillin/clavulanate.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported with beta-lactams, more likely with a history of penicillin hypersensitivity; ask about previous reactions before starting and discontinue if an allergic reaction occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Severe cutaneous adverse reactions (SJS, TEN, DRESS, AGEP) and drug-induced enterocolitis syndrome (DIES, protracted vomiting 1-4 hours after a dose, mostly in children) may occur; discontinue if they develop.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hepatic dysfunction, including hepatitis and cholestatic jaundice, has been associated with amoxicillin/clavulanate; it is usually reversible but deaths have been reported; monitor hepatic function at regular intervals in patients with hepatic impairment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• ProbenecidDecreases renal tubular secretion of amoxicillin (not clavulanic acid), resulting in increased and prolonged amoxicillin levels; co-administration is not recommended.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulantsAbnormal prolongation of prothrombin time (increased INR) has been reported; monitor and adjust the anticoagulant dose if necessary.DailyMed (U.S. National Library of Medicine)
• AllopurinolConcurrent use with amoxicillin substantially increases the incidence of rashes.DailyMed (U.S. National Library of Medicine)

• Reproduction studies in pregnant rats and mice at oral doses up to 1200 mg/kg/day revealed no evidence of fetal harm; there are no adequate and well-controlled studies in pregnant women; use during pregnancy only if clearly needed. Oral ampicillin-class antibacterials are poorly absorbed during labor.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Amoxicillin is excreted in human milk; use by nursing mothers may lead to sensitization of infants - exercise caution.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Amoxicillin: Bactericidal penicillin that inhibits bacterial cell-wall biosynthesis; susceptible to degradation by beta-lactamases, which clavulanic acid inhibits.
• Clavulanic acid: Beta-lactam structurally related to the penicillins that inactivates many beta-lactamase enzymes, protecting amoxicillin from degradation and extending its antibacterial spectrum.