سعر اموفلوكسين 500 مجم فيال 2022

Amoxicillin + flucloxacillin 500 mg (total) vial for injection; penicillin antibiotic combination.

• Infections of the ear, nose and throat, genitourinary tract, skin and skin structure, and lower respiratory tract due to susceptible (beta-lactamase-negative) isolates of designated bacteriaPopulation: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Helicobacter pylori infection and duodenal ulcer disease in adults, in triple therapy with clarithromycin and lansoprazole or dual therapy with lansoprazolePopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Infections due to sensitive Gram-positive organisms including beta-lactamase-producing staphylococci and streptococci: skin and soft-tissue infections, respiratory tract infections, otitis media/externa, and other infections (osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, septicaemia); surgical prophylaxisPopulation: Adults and childrenelectronic medicines compendium (emc), UK

• Most common adverse reactions (>1%) in clinical trials of capsules, tablets or oral suspension: diarrhea, rash, vomiting and nausea.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Postmarketing reports include mucocutaneous candidiasis, hemorrhagic/pseudomembranous colitis, hypersensitivity reactions including anaphylaxis, serum sickness-like reactions, SJS/TEN/DRESS/AGEP, hepatic dysfunction including cholestatic jaundice, crystalluria and blood dyscrasias (anemia, thrombocytopenia, eosinophilia, leukopenia, agranulocytosis).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Flucloxacillin: common minor gastrointestinal disturbances; uncommon rash, urticaria and purpura; very rare hepatitis/cholestatic jaundice, neutropenia/agranulocytosis, thrombocytopenia, anaphylaxis, pseudomembranous colitis, erythema multiforme/SJS/TEN, interstitial nephritis; not known: AGEP, hypokalaemia, oesophageal pain.General active-ingredient information · electronic medicines compendium (emc), UK

• History of a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to amoxicillin or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to flucloxacillin, any excipient or other beta-lactam antibiotics (penicillins, cephalosporins); previous history of flucloxacillin-associated jaundice/hepatic dysfunction.General active-ingredient information · electronic medicines compendium (emc), UK

• Serious and occasionally fatal anaphylactic reactions have been reported with penicillins; inquire about previous hypersensitivity to penicillins, cephalosporins or other allergens before starting; discontinue if an allergic reaction occurs.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Severe cutaneous adverse reactions (SJS, TEN, DRESS, AGEP) and drug-induced enterocolitis syndrome (mostly in pediatric patients) may occur; discontinue if lesions progress or DIES occurs.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhea may occur (even more than 2 months after treatment); a high percentage of patients with mononucleosis develop erythematous rash - amoxicillin should not be given to patients with mononucleosis; prescribe only for proven or strongly suspected bacterial infection.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• ProbenecidDecreases renal tubular secretion of amoxicillin, resulting in increased and prolonged blood levels.DailyMed (U.S. National Library of Medicine)
• Oral anticoagulants (e.g., warfarin)Abnormal prolongation of prothrombin time (increased INR) has been reported; monitor and adjust the anticoagulant dose if necessary.DailyMed (U.S. National Library of Medicine)
• AllopurinolConcurrent use increases the incidence of rashes.DailyMed (U.S. National Library of Medicine)

• Reproduction studies in mice and rats at up to 2000 mg/kg showed no evidence of fetal harm; there are no adequate and well-controlled studies in pregnant women; use during pregnancy only if clearly needed.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Flucloxacillin: animal studies showed no teratogenic effects and limited human pregnancy data show no evidence of untoward effects; use in pregnancy only when potential benefits outweigh risks.General active-ingredient information · electronic medicines compendium (emc), UK
• Penicillins are excreted in human milk; amoxicillin use by nursing mothers may lead to sensitization of infants - exercise caution.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Amoxicillin: Bactericidal beta-lactam that inhibits bacterial cell-wall biosynthesis during active multiplication; inactivated by beta-lactamases (US label, section 12.4).
• Flucloxacillin: Isoxazolyl penicillin of the beta-lactam group with bactericidal activity against many Gram-positive organisms, including beta-lactamase-producing staphylococci and streptococci (UK SmPC).