سعر إمباسيريل 10/5 مجم 2026

Film-coated tablets empagliflozin 10 mg / linagliptin 5 mg; pack of 30.

• Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (US label for equivalent formulation).Population: Adults with type 2 diabetesDailyMed (U.S. NLM)

• Common: urinary tract infection, genital mycotic infection, increased urination, thirst, nasopharyngitis; with metformin also GI upset (diarrhea, nausea). Laboratory: increased LDL-C, increased hematocrit (US labels).International label, equivalent formulation · DailyMed (U.S. NLM)

• History of serious hypersensitivity to empagliflozin (and linagliptin if combination) or any product component; patients on dialysis (US SGLT2/DPP-4 combination labels).International label, equivalent formulation · DailyMed (U.S. NLM)

• Ketoacidosis (including euglycemic), volume depletion, urosepsis/pyelonephritis, genital mycotic infections, hypoglycemia with insulin/sulfonylurea, necrotizing fasciitis of the perineum (Fournier gangrene) reported with SGLT2 inhibitors (US labels).International label, equivalent formulation · DailyMed (U.S. NLM)
• DPP-4 inhibitors including linagliptin: postmarketing reports of acute pancreatitis and severe joint pain; discontinue if pancreatitis suspected.International label, equivalent formulation · DailyMed (U.S. NLM)

• Insulin or insulin secretagogues (e.g. sulfonylureas)MajorIncreased risk of hypoglycemia; consider lower dose of insulin/secretagogue when coadministered.DailyMed (U.S. NLM)

• US labels advise against use in second/third trimester based on animal data showing adverse renal effects of SGLT2 inhibitors; counsel and use alternative therapy when pregnancy recognized.International label, equivalent formulation · DailyMed (U.S. NLM)
• Not recommended while breastfeeding (US labels: risk of serious adverse reactions in breastfed infant from SGLT2/metformin exposure).International label, equivalent formulation · DailyMed (U.S. NLM)

• Empagliflozin: Inhibits SGLT2 in the proximal renal tubule, reducing renal reabsorption of filtered glucose and lowering the renal threshold for glucose, thereby increasing urinary glucose excretion (US label).
• Linagliptin: Inhibits DPP-4, increasing incretin (GLP-1/GIP) levels which enhance glucose-dependent insulin secretion.