سعر ايبوسين 20 مجم / مل فيال 2022

Etoposide 20 mg/ml concentrate for solution for IV infusion, vial (Eposin; Pharmachemie, Netherlands; distributed by Copad Pharma).

• Refractory testicular tumors, in combination with other approved chemotherapeutic agents, in patients who have already received appropriate surgery, chemotherapy and radiotherapy.Population: AdultsDailyMed (U.S. NLM)
• First-line treatment of small cell lung cancer in combination with other approved chemotherapeutic agents.Population: AdultsDailyMed (U.S. NLM)

• Dose-limiting myelosuppression (granulocyte nadir day 7-14, platelet nadir day 9-16); nausea and vomiting; mucositis; transient hypotension after rapid IV administration (1-2%).International label, equivalent formulation · DailyMed (U.S. NLM)

• Previous hypersensitivity to etoposide or any component of the formulation.International label, equivalent formulation · DailyMed (U.S. NLM)

• Boxed warning: administer under the supervision of a physician experienced in cancer chemotherapy; severe myelosuppression with resulting infection or bleeding may occur.International label, equivalent formulation · DailyMed (U.S. NLM)
• Anaphylactic-like reactions (chills, fever, tachycardia, bronchospasm, dyspnea, hypotension) may occur; stop the infusion immediately and treat symptomatically. Etoposide should be considered a potential carcinogen (secondary leukemia reported).International label, equivalent formulation · DailyMed (U.S. NLM)

• Etoposide can cause fetal harm (teratogenic in mice and rats); women of childbearing potential should avoid becoming pregnant.International label, equivalent formulation · DailyMed (U.S. NLM)
• Unknown whether excreted in human milk; because of potential serious adverse reactions, decide whether to discontinue nursing or the drug.International label, equivalent formulation · DailyMed (U.S. NLM)

• Etoposide: Semisynthetic podophyllotoxin derivative; inhibits topoisomerase II causing DNA strand breaks and arrest in late S/G2 phase (US etoposide labeling).