سعر إيمثيكسات بي إف 25 مجم/مل (50 مجم) فيال 2026

Preservative-free methotrexate injection 25 mg/mL; 50 mg vial (2 mL). Egyptian listing via Dalil Al Dwaa; MAH/distributor Copad Pharma, originator Pharmachemie Netherlands.

• Directory lists oncology and autoimmune uses for methotrexate class (ALL, choriocarcinoma, lymphomas, psoriasis, rheumatoid arthritis, osteosarcoma, etc.). Exact Egyptian Emthexate PF labeled indications not opened — treat as class listing only.
• US methotrexate injection labels cover neoplastic diseases and selected non-malignant conditions per specific dosing regimens (oncology vs low-dose rheumatology protocols differ substantially).DailyMed (U.S. NLM)

• Pregnancy (embryotoxic/teratogenic), breastfeeding, severe hepatic/renal impairment as labeled, pre-existing blood dyscrasias, immunodeficiency syndromes, hypersensitivity to methotrexate (US injection labels).International label, equivalent formulation · DailyMed (U.S. NLM)

• US boxed warnings: serious toxic reactions including myelosuppression, hepatotoxicity, pneumonitis, GI toxicity; high-dose regimens require leucovorin rescue and institutional protocols. Fatal dosing errors reported when daily vs weekly regimens confused.International label, equivalent formulation · DailyMed (U.S. NLM)

• NSAIDs, penicillins, proton pump inhibitors, trimethoprim/sulfamethoxazoleMajorMay increase methotrexate levels/toxicity via reduced renal clearance or antifolate synergy; monitor closely.DailyMed (U.S. NLM)

• Methotrexate is contraindicated in pregnancy for non-neoplastic diseases; embryotoxic and teratogenic. Effective contraception required for patients of reproductive potential as labeled.International label, equivalent formulation · DailyMed (U.S. NLM)

• Methotrexate: Inhibits dihydrofolate reductase (DHFR), blocking tetrahydrofolate formation needed for thymidine and purine synthesis, thereby inhibiting DNA/RNA/protein synthesis.