سعر ايفاستين 10 مجم 2024

Ebastine 10 mg film-coated tablets (Marcyrl, Egypt), pack of 20 tablets (2 strips); second-generation H1 antihistamine.

• Symptomatic treatment of allergic rhinitis (seasonal or perennial) with or without allergic conjunctivitis.Population: Adults and adolescents over 12 yearsCIMA - Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)
• Symptomatic treatment of chronic idiopathic urticaria.Population: Adults and adolescents over 12 yearsCIMA - Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)
• Allergic dermatitis.Population: Adults and adolescents over 12 yearsCIMA - Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)

• Very common: headache. Common: somnolence, dry mouth. Rare: hypersensitivity reactions (anaphylaxis, angioedema), nervousness, insomnia, dizziness, hypoaesthesia, dysgeusia, palpitations, tachycardia, abdominal pain, vomiting, nausea, dyspepsia, hepatitis/cholestasis/abnormal liver tests, urticaria, rash, dermatitis, menstrual disorders, oedema, asthenia. Frequency not known: increased appetite, weight gain.International label, same formulation · CIMA - Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)

• Hypersensitivity to ebastine or to any excipient.International label, same formulation · CIMA - Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)

• Use with caution in patients with known QT prolongation risk or hypokalaemia, and with drugs that prolong QT or inhibit CYP3A4 (e.g. ketoconazole, itraconazole, erythromycin); caution with rifampicin; caution in severe hepatic impairment; onset of action is 1-3 hours, so not for acute allergic emergencies; contains lactose.International label, same formulation · CIMA - Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)

• Azole antifungals (ketoconazole, itraconazole) and macrolides (erythromycin)Increase plasma levels of ebastine and, to a lesser extent, carebastine; QTc increased by about 10 ms more than with either drug alone; use with caution.CIMA - Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)
• RifampicinPharmacokinetic interaction can lower ebastine plasma levels and reduce the antihistamine effect.CIMA - Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)
• Allergy skin testsEbastine may interfere with allergy skin test results; it is recommended to stop it 5-7 days before testing.CIMA - Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)

• Limited data in pregnancy; as a precaution it is preferable to avoid ebastine during pregnancy.International label, same formulation · CIMA - Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)
• Excretion in human milk is unknown; high protein binding suggests no excretion, but as a precaution it is preferable to avoid use during breastfeeding.International label, same formulation · CIMA - Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)

• Ebastine: Long-acting selective peripheral H1 antagonist; acts mainly through its active metabolite carebastine (formed via CYP3A4) and does not appreciably cross the blood-brain barrier at therapeutic doses.