سعر فلوتيفورم استنشاق 10/250ميكروجرام 120 جرعه متساوية 2022

Flutiform pressurised metered-dose inhaler, fluticasone propionate 250 mcg / formoterol fumarate dihydrate 10 mcg per actuation, 120 actuations (Mundipharma; Multipharma, Egypt); fixed-dose combination for regular treatment of asthma.

• Regular treatment of asthma where a combination of an inhaled corticosteroid and a long-acting beta-2 agonist is appropriate: patients not adequately controlled on inhaled corticosteroids with as-required short-acting beta-2 agonist, or already controlled on both an inhaled corticosteroid and a LABA.Population: Adultselectronic medicines compendium (eMC)

• Uncommon: headache, tremor, dizziness, sleep disorders including insomnia, palpitations, ventricular extrasystoles; rare: oral candidiasis and fungal infections, sinusitis, hyperglycaemia, abnormal dreams, agitation, dysgeusia, vertigo.International label, same formulation · electronic medicines compendium (eMC)

• Hypersensitivity to the active substances or to any of the excipients.International label, same formulation · electronic medicines compendium (eMC)

• Not for relief of acute asthma symptoms; patients should always carry a fast-acting reliever. Do not initiate during an exacerbation or significantly worsening asthma, and do not stop abruptly.International label, same formulation · electronic medicines compendium (eMC)
• Not to be used in COPD (no data).International label, same formulation · electronic medicines compendium (eMC)
• Increasing reliever use or uncontrolled symptoms indicate deterioration and require prompt medical review.International label, same formulation · electronic medicines compendium (eMC)

• Strong CYP3A inhibitors (ritonavir, cobicistat, ketoconazole, itraconazole, clarithromycin, etc.)Fluticasone propionate is a CYP3A4 substrate; co-treatment increases the risk of systemic corticosteroid effects; avoid unless benefit outweighs risk, then monitor.electronic medicines compendium (eMC)
• Non-potassium-sparing diuretics, xanthines, systemic glucocorticoidsMay worsen hypokalaemia and ECG changes from beta-agonists; use with caution.electronic medicines compendium (eMC)

• Limited data in pregnancy and reproductive toxicity in animals; not recommended during pregnancy unless the expected benefit to the mother outweighs any risk to the fetus, then use the lowest effective dose; use during labour should be restricted.International label, same formulation · electronic medicines compendium (eMC)
• Unknown whether excreted in human milk; a risk to the suckling child cannot be excluded; decide whether to stop breastfeeding or the medicine.International label, same formulation · electronic medicines compendium (eMC)

• Fluticasone propionate: Potent glucocorticoid-receptor agonist with anti-inflammatory activity; precise mechanism in allergic rhinitis unknown.
• Formoterol fumarate: Stimulates beta-2 adrenoceptors, activating adenylyl cyclase and raising cyclic AMP, which relaxes bronchial smooth muscle; bronchodilation lasts about 12 hours.