سعر ميتكلاميد 2.5/500مجم 30 قرص 2023

Fixed-dose oral tablet containing glibenclamide (glyburide) 2.5 mg and metformin hydrochloride 500 mg, pack of 30 tablets; Egyptian product by EPCI.

• Adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitusPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Common: upper respiratory infection, diarrhoea, headache, nausea/vomiting, abdominal pain, dizziness and hypoglycaemia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Severe renal impairment (eGFR below 30 mL/min/1.73 m2).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to metformin or glyburide.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: metformin-associated lactic acidosis (can be fatal); risk factors include renal impairment, age 65 or older, iodinated contrast, surgery, hypoxia, excessive alcohol and hepatic impairment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypoglycaemia, which may be severe, especially in elderly, renally impaired or malnourished patients and with other antidiabetic drugs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Metformin may lower vitamin B12 levels; measure haematological parameters periodically. Temporarily stop before iodinated contrast procedures in at-risk patients.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• BosentanContraindicated with glyburide (risk of liver enzyme elevation).DailyMed (U.S. National Library of Medicine)
• Carbonic anhydrase inhibitors (e.g. topiramate) and drugs reducing metformin clearanceMay increase the risk of lactic acidosis; monitor.DailyMed (U.S. National Library of Medicine)

• Limited data with glyburide/metformin in pregnancy; poorly controlled diabetes carries maternal and fetal risks. Neonatal hypoglycaemia may occur after sulfonylurea exposure near term.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Metformin is present in human milk; monitor breastfed infants for hypoglycaemia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Glibenclamide (glyburide): Stimulates insulin release from functioning pancreatic beta cells (US label).
• Metformin hydrochloride: Decreases hepatic glucose production and intestinal glucose absorption and improves insulin sensitivity (US label).