سعر فريشموند قطرة عين 2.5 مل 2023

Travoprost 0.004% + timolol 0.5% eye drops (2.5 ml) for lowering raised intraocular pressure in glaucoma.

• Decrease of intraocular pressure in adults with open-angle glaucoma or ocular hypertension who are insufficiently responsive to topical beta-blockers or prostaglandin analogues.Population: Adultselectronic medicines compendium (emc), UK

• Most frequent: ocular hyperaemia (12%); common: punctate keratitis, eye pain, visual disturbance, blurred vision, dry eye, eye pruritus, ocular discomfort and irritation. Uncommon systemic effects include bradycardia, dizziness, headache, hypertension/hypotension and dyspnoea; iris hyperpigmentation and eyelash growth may occur.International label, same formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to the active substances, excipients or other beta-blockers; reactive airway disease including asthma or history of asthma, severe COPD; sinus bradycardia, sick sinus syndrome, sino-atrial block, uncontrolled second- or third-degree AV block; overt cardiac failure, cardiogenic shock; severe allergic rhinitis and corneal dystrophies.International label, same formulation · electronic medicines compendium (emc), UK

• Timolol is absorbed systemically and may cause the cardiovascular, pulmonary and other effects of systemic beta-blockers; use cautiously in cardiovascular disease, first-degree heart block, severe peripheral circulatory disorders, mild/moderate COPD, labile diabetes or spontaneous hypoglycaemia (signs may be masked), hyperthyroidism (signs may be masked) and myasthenia.International label, same formulation · electronic medicines compendium (emc), UK
• Travoprost may gradually and permanently increase brown pigmentation of the iris (heterochromia if one eye is treated), and may cause periorbital/eyelid skin darkening and eyelash changes; patients must be informed before treatment.International label, same formulation · electronic medicines compendium (emc), UK
• Avoid using two topical beta-blockers or two local prostaglandins together; inform the anaesthetist before surgery; prostaglandin analogues can be absorbed through the skin, so pregnant women or those trying to conceive should avoid direct exposure to the bottle contents.International label, same formulation · electronic medicines compendium (emc), UK

• Oral calcium channel blockers, systemic beta-blockers, antiarrhythmics (including amiodarone), digitalis glycosides, parasympathomimetics, guanethidinePotential additive effects causing hypotension and/or marked bradycardia.electronic medicines compendium (emc), UK
• CYP2D6 inhibitors (e.g. quinidine, fluoxetine, paroxetine)Potentiated systemic beta-blockade (reduced heart rate, depression) reported with timolol.electronic medicines compendium (emc), UK
• Clonidine (withdrawal)Rebound hypertension after sudden clonidine withdrawal may be potentiated by beta-blockers.electronic medicines compendium (emc), UK

• Travoprost has harmful pharmacological effects on pregnancy and/or the foetus; women of childbearing potential must not use it without adequate contraception. Do not use in pregnancy unless clearly necessary.International label, same formulation · electronic medicines compendium (emc), UK
• Timolol is excreted in breast milk and travoprost appears in animal milk; use while breast-feeding is not recommended.International label, same formulation · electronic medicines compendium (emc), UK

• Travoprost: Selective FP prostanoid receptor agonist that lowers intraocular pressure by increasing aqueous humour outflow through trabecular meshwork and uveoscleral pathways.
• Timolol: Non-selective beta-blocker that lowers intraocular pressure mainly by reducing aqueous humour formation.