سعر جيموكساسين 320مجم 5 قرص 2022

Gemifloxacin 320 mg film-coated tablets, pack of 5, listed in Egypt under El-Obour (Dawaa Pharma); fluoroquinolone antibiotic.

• Acute bacterial exacerbation of chronic bronchitis caused by susceptible S. pneumoniae, H. influenzae, H. parainfluenzae or M. catarrhalis; reserve for patients with no alternative treatment options.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Community-acquired pneumonia of mild to moderate severity caused by susceptible organisms (including multi-drug-resistant S. pneumoniae).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse events (2% or more) in trials: diarrhoea 5.0%, headache 4.2%, nausea 3.7%, rash 3.5%, abdominal pain 2.2%; vomiting and dizziness less often.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity to gemifloxacin, fluoroquinolone antibacterials or any product component.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: fluoroquinolones are associated with disabling and potentially irreversible serious reactions, including tendinitis and tendon rupture, peripheral neuropathy and central nervous system effects; discontinue immediately if these occur. May exacerbate muscle weakness in myasthenia gravis; avoid in patients with a history of myasthenia gravis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• May prolong the QT interval: avoid in patients with QTc prolongation, uncorrected hypokalaemia or hypomagnesaemia, and with class IA or class III antiarrhythmics.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Rash occurred more often than with comparators, especially in patients under 40, women, those on hormone replacement therapy and with longer therapy; discontinue if rash or urticaria develops.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Aluminium/magnesium antacids, iron, zinc or other metal-cation multivitamins, didanosine buffered formulationsMarkedly reduce gemifloxacin absorption (AUC -85% with Al/Mg antacid); do not take within 3 hours before or 2 hours after gemifloxacin.DailyMed (U.S. National Library of Medicine)
• Class IA (quinidine, procainamide) and class III (amiodarone, sotalol) antiarrhythmicsAvoid because of QT prolongation risk.DailyMed (U.S. National Library of Medicine)

• Fetal growth retardation was seen in mice, rats and rabbits at 2-4 times human exposure, and fetal brain and ocular malformations in rats at 8 times clinical exposure with maternal toxicity; no adequate human studies.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Gemifloxacin: Inhibits bacterial DNA synthesis by inhibiting DNA gyrase (topoisomerase II) and topoisomerase IV.