سعر سبترين أطفال معلق 120 مل 2024

Septrin Paediatric is a GSK co-trimoxazole oral suspension labelled 200/40 (sulfamethoxazole 200 mg + trimethoprim 40 mg, per Lotus: banana flavour, sugar free), 120 ml bottle, sold in Egypt.

• Treatment and prevention of Pneumocystis jirovecii pneumonitis (PJP)Population: Children aged 6 weeks to 12 yearselectronic medicines compendium (emc), UK
• Treatment and prophylaxis of toxoplasmosisPopulation: Children aged 6 weeks to 12 yearselectronic medicines compendium (emc), UK
• Treatment of nocardiosisPopulation: Children aged 6 weeks to 12 yearselectronic medicines compendium (emc), UK

• Very common: hyperkalaemia. Common: fungal overgrowth. Very rare: blood dyscrasias (leukopenia, neutropenia, thrombocytopenia, agranulocytosis, megaloblastic, aplastic or haemolytic anaemia), serum sickness, anaphylaxis, hypoglycaemia, hyponatraemia, metabolic acidosis and pseudomembranous colitis.International label, same formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to sulphonamides, trimethoprim, co-trimoxazole or any excipient; severe liver impairment; severe renal insufficiency where plasma levels cannot be measured repeatedly; infants in the first 6 weeks of life; history of drug-induced immune thrombocytopenia with trimethoprim and/or sulphonamides; acute porphyria; first trimester of pregnancy.International label, same formulation · electronic medicines compendium (emc), UK
• US label: known hypersensitivity to trimethoprim or sulfonamides; history of drug-induced immune thrombocytopenia; documented megaloblastic anaemia due to folate deficiency; paediatric patients under 2 months; marked hepatic damage; severe renal insufficiency when renal function cannot be monitored; co-administration with dofetilide.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Rare but fatal severe reactions have occurred (Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS, fulminant hepatic necrosis, agranulocytosis, aplastic anaemia and other blood dyscrasias); stop at the first sign of a severe skin reaction and never restart after SJS/TEN/DRESS. AGEP, haemophagocytic lymphohistiocytosis and severe respiratory toxicity (ARDS) have also been reported.International label, same formulation · electronic medicines compendium (emc), UK
• Use with particular care in the elderly, in renal impairment (adjust dose), folate deficiency, G6PD deficiency (haemolysis), severe atopy or asthma, porphyria risk, and patients at risk of hyperkalaemia, hyponatraemia or metabolic acidosis; maintain adequate urine output. Not to be used for group A streptococcal pharyngitis.International label, same formulation · electronic medicines compendium (emc), UK
• UK suspension contains sorbitol (3.25 g per 5 ml); patients with hereditary fructose intolerance should not take it. Egyptian excipients were not verified.International label, same formulation · electronic medicines compendium (emc), UK

• WarfarinCo-trimoxazole potentiates the anticoagulant effect of warfarin; careful anticoagulation control is advised.electronic medicines compendium (emc), UK
• MethotrexateMay increase free plasma methotrexate; consider folate supplementation; trimethoprim interferes with some methotrexate assays.electronic medicines compendium (emc), UK
• PhenytoinProlongs phenytoin half-life; monitor clinical status and serum phenytoin.electronic medicines compendium (emc), UK

• US label: some epidemiological studies suggest an increased risk of congenital malformations (neural tube, cardiovascular and urinary tract defects, oral clefts, club foot); advise the patient of the potential foetal hazard if used in pregnancy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Both components are excreted in breast milk; avoid in late pregnancy and in lactating mothers where mother or infant has, or is at particular risk of, hyperbilirubinaemia, and avoid in infants younger than eight weeks.International label, same formulation · electronic medicines compendium (emc), UK
• US label: milk levels are about 2-5% of the recommended infant daily dose; use caution, especially when breastfeeding jaundiced, ill, stressed or premature infants (bilirubin displacement and kernicterus risk).International label, same formulation · DailyMed (U.S. National Library of Medicine)

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