سعر هيرباكوت 500 مجم 10 أقراص 2022

Herpacut 500 mg valacyclovir scored film-coated tablets, pack of 10, marketed in Egypt by International Drug Agency (IDI); antiviral prodrug of aciclovir.

• Adults: cold sores (herpes labialis); genital herpes - treatment of initial or recurrent episodes in immunocompetent adults, suppressive therapy in immunocompetent or HIV-1-infected adults and reduction of transmission; herpes zoster.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Pediatric: cold sores (12 years and older) and chickenpox (2 to less than 18 years).Population: Pediatric patientsDailyMed (U.S. National Library of Medicine)

• Most common in adults (>10%): headache, nausea and abdominal pain; in pediatric patients: headache.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Clinically significant hypersensitivity reaction (e.g. anaphylaxis, severe cutaneous adverse reactions) to valacyclovir, acyclovir or any component of the formulation.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome has occurred in advanced HIV disease and transplant patients receiving 8 g/day; discontinue if suspected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Acute renal failure and CNS adverse reactions (agitation, hallucinations, confusion, encephalopathy), especially in the elderly, in renal impairment with excessive doses, with nephrotoxic drugs or inadequate hydration; reduce dose in renal impairment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Severe cutaneous adverse reactions (AGEP, DRESS, TEN, Stevens-Johnson syndrome) reported post-marketing.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Other drugs and foodNo clinically significant drug-drug or drug-food interactions are known (US label).DailyMed (U.S. National Library of Medicine)

• Decades of clinical data with valacyclovir and acyclovir in pregnancy have not identified a drug-associated risk of major birth defects; data on miscarriage or other outcomes are insufficient; untreated herpes simplex carries fetal risks.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Acyclovir (the metabolite) is present in human milk; 500 mg twice daily gives the infant about 0.6 mg/kg/day of acyclovir; no data on effects on the breastfed child or milk production.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Valacyclovir (valaciclovir): Prodrug rapidly converted to aciclovir, which after phosphorylation inhibits herpesvirus DNA polymerase; active against alpha-herpesviruses (HSV-1, HSV-2, VZV).