سعر لوفير 400مجم 10 اقراص 2024

Aciclovir 400 mg dispersible tablets (Global Napi Pharmaceuticals (for Ranbaxy)); antiviral for herpes simplex and varicella-zoster infections.

• Treatment of herpes simplex virus infections of the skin and mucous membranes, including initial and recurrent genital herpes (excluding neonatal HSV and severe HSV infections in immunocompromised children)Population: Adults and childrenelectronic medicines compendium (emc), UK
• Suppression of recurrent herpes simplex virus infectionsPopulation: Immunocompetent patientselectronic medicines compendium (emc), UK
• Prevention of herpes simplex virus infections in immunocompromised patientsPopulation: Immunocompromised patientselectronic medicines compendium (emc), UK

• Common: headache, dizziness, nausea, vomiting, diarrhoea, abdominal pain, pruritus, rash (including photosensitivity), fatigue, fever. Very rare: agitation, confusion, tremor, hallucinations, convulsions, encephalopathy (mostly with renal impairment), hepatitis, acute renal failure.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to aciclovir, valaciclovir or any excipient.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Severe cutaneous adverse reactions (TEN, SJS, AGEP, DRESS, erythema multiforme) have been reported; discontinue immediately if signs appear.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Adjust the dose in renal impairment and in the elderly; both groups are at increased risk of neurological adverse effects and should be monitored.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Maintain adequate hydration with high oral doses; the risk of renal impairment increases with other nephrotoxic drugs.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Probenecid and cimetidineIncrease aciclovir AUC and reduce its renal clearance; no dose adjustment needed because of the wide therapeutic index.electronic medicines compendium (emc), UK
• Mycophenolate mofetilPlasma AUCs of aciclovir and the inactive mycophenolate metabolite increase when co-administered; no dose adjustment needed.electronic medicines compendium (emc), UK
• TheophyllineAciclovir may increase theophylline exposure; monitoring of theophylline plasma levels is recommended.electronic medicines compendium (emc), UK

• Use only when potential benefits outweigh unknown risks; a post-marketing pregnancy registry has not shown an increase in birth defects among aciclovir-exposed pregnancies.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Aciclovir passes into breast milk (0.6-4.1 times plasma levels after 200 mg five times daily); caution is advised in nursing women.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Aciclovir (acyclovir): Synthetic purine nucleoside analogue; viral thymidine kinase of HSV/VZV converts it to the monophosphate and cellular enzymes to the triphosphate, which interferes with viral DNA polymerase and replication.