سعر هاي جليتازون 30 مجم 30 قرص 2023

Pioglitazone 30 mg tablets (Hi-Pharm), 30 tablets; thiazolidinedione insulin sensitiser for type 2 diabetes.

• Adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus (not for type 1 diabetes or diabetic ketoacidosis).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>=5%): upper respiratory tract infection, headache, sinusitis, myalgia, pharyngitis.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Initiation in established NYHA class III or IV heart failure.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Known hypersensitivity to pioglitazone or any component.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: thiazolidinediones cause or exacerbate congestive heart failure; monitor for weight gain, dyspnoea and oedema after starting and dose increases; not recommended in symptomatic heart failure.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hypoglycaemia with insulin or insulin secretagogues (lower their dose); postmarketing hepatic failure (interrupt if liver injury); possible increased bladder cancer risk (do not use in active bladder cancer); oedema and fractures.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP2C8 inhibitors (e.g. gemfibrozil)Increase pioglitazone exposure; limit the dose to 15 mg daily.DailyMed (U.S. National Library of Medicine)
• CYP2C8 inducers (e.g. rifampin)May decrease pioglitazone concentrations.DailyMed (U.S. National Library of Medicine)
• TopiramateMay decrease pioglitazone concentrations.DailyMed (U.S. National Library of Medicine)

• Limited human data are insufficient to determine a drug-associated risk; poorly controlled diabetes carries maternal and fetal risks; no adverse developmental effects in rats and rabbits at exposures up to 5 and 35 times the 45 mg dose.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• No information on presence in human milk; present in rat milk. Weigh benefits of breastfeeding against the mother's need and potential infant effects.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Pioglitazone: Thiazolidinedione that depends on the presence of insulin; decreases insulin resistance in the periphery and liver via PPAR-gamma agonism.