سعر هيدروكورتيزون صوديوم ساكسينات 100 مجم فيال 2024

Hydrocortisone sodium succinate 100 mg powder for IV/IM injection, single vial (EIPICO, Egypt).

• When oral therapy is not feasible: control of severe or incapacitating allergic states (e.g. asthma, atopic or contact dermatitis, drug hypersensitivity reactions, serum sickness, transfusion reactions).DailyMed (US National Library of Medicine)
• Endocrine disorders: primary or secondary adrenocortical insufficiency (hydrocortisone is the drug of choice), congenital adrenal hyperplasia, hypercalcaemia associated with cancer, nonsuppurative thyroiditis.DailyMed (US National Library of Medicine)
• Other corticosteroid-responsive conditions: dermatologic, gastrointestinal (ulcerative colitis, regional enteritis), haematologic, neoplastic (palliation of leukaemias/lymphomas), nervous system (cerebral oedema), ophthalmic, renal, respiratory and rheumatic disorders as listed in the label.DailyMed (US National Library of Medicine)

• Reported reactions include hypersensitivity/anaphylaxis, fluid and electrolyte disturbances (sodium retention, hypokalaemic alkalosis), hypertension, hyperglycaemia and cushingoid state, peptic ulcer, impaired wound healing, skin atrophy, muscle weakness, osteoporosis, mood and psychiatric changes, increased intraocular pressure and cataract.International label, same formulation · DailyMed (US National Library of Medicine)

• Systemic fungal infections and known hypersensitivity to the product or its constituents.International label, same formulation · DailyMed (US National Library of Medicine)
• Intrathecal administration (severe medical events reported); intramuscular use in idiopathic thrombocytopenic purpura.International label, same formulation · DailyMed (US National Library of Medicine)

• Immunosuppression increases the risk and severity of infections (bacterial, viral, fungal, parasitic), may mask signs of infection and reactivate latent tuberculosis, hepatitis B, amoebiasis or Strongyloides; avoid live vaccines at immunosuppressive doses; avoid in cerebral malaria.International label, same formulation · DailyMed (US National Library of Medicine)
• HPA-axis suppression, Cushing syndrome and hyperglycaemia with prolonged use; secondary adrenal insufficiency may persist for months after withdrawal, so increase cover during stress and taper gradually.International label, same formulation · DailyMed (US National Library of Medicine)
• Fluid/sodium retention, hypertension and potassium loss; caution in heart failure, hypertension, renal insufficiency and after recent myocardial infarction. High doses should not be used for traumatic brain injury.International label, same formulation · DailyMed (US National Library of Medicine)

• Strong CYP3A4 inhibitors (ketoconazole, macrolide antibiotics)May increase corticosteroid plasma concentrations and side effects.DailyMed (US National Library of Medicine)
• CYP3A4 inducers (barbiturates, phenytoin, carbamazepine, rifampin)May enhance corticosteroid metabolism; dose increase may be required.DailyMed (US National Library of Medicine)
• Potassium-depleting agents (diuretics, amphotericin B), digitalis glycosidesRisk of hypokalaemia (and arrhythmias with digitalis); cardiac enlargement and heart failure reported with amphotericin B.DailyMed (US National Library of Medicine)

• Corticosteroids are teratogenic in animals (cleft palate); no adequate studies in pregnant women; use only if the potential benefit justifies the potential risk to the fetus.International label, same formulation · DailyMed (US National Library of Medicine)
• Systemic corticosteroids appear in human milk and could suppress growth or endogenous corticosteroid production; decide whether to discontinue nursing or the drug.International label, same formulation · DailyMed (US National Library of Medicine)

• Hydrocortisone sodium succinate: Binds intracellular glucocorticoid receptors and modifies gene transcription, producing anti-inflammatory, immunosuppressive and metabolic effects; also has mineralocorticoid (salt-retaining) activity.