سعر ايبوفلكس 20 قرص 2023

Ibuflex tablets (ibuprofen 400 mg + methocarbamol 750 mg per tablet as stated by Egyptian directories), pack of 20, by Global Napi Pharmaceuticals (Egypt); analgesic and muscle relaxant combination.

• The most frequent adverse reactions are gastrointestinal: in controlled trials 4% to 16% of patients reported one or more GI complaints (e.g. nausea, epigastric pain, heartburn, diarrhoea, abdominal distress, vomiting, indigestion, constipation, cramps, bloating); dizziness and rash were also among the more frequent reactions.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Adverse reactions reported with methocarbamol include drowsiness, dizziness or lightheadedness, sedation, headache, nausea and vomiting, dyspepsia, blurred vision, rash, pruritus, urticaria, hypersensitivity reactions (including anaphylaxis and angioneurotic oedema), bradycardia, hypotension, jaundice and leukopenia.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Contraindicated in patients with known hypersensitivity to ibuprofen; in patients who have experienced asthma, urticaria or allergic-type reactions after taking aspirin or other NSAIDs; and in the setting of coronary artery bypass graft (CABG) surgery.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Methocarbamol is contraindicated in patients hypersensitive to methocarbamol or to any of the tablet components.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Boxed warning: NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal; the risk may occur early in treatment and may increase with duration of use.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• NSAIDs can cause new or worsened hypertension, fluid retention and oedema, and may blunt the effects of diuretics, ACE inhibitors or ARBs; monitor blood pressure closely.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Long-term NSAID administration has resulted in renal papillary necrosis and other renal injury; patients with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, and the elderly are at greatest risk.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Methocarbamol may have a general CNS-depressant effect: patients should be cautioned about combined effects with alcohol and other CNS depressants, and that it may cause drowsiness or dizziness impairing the ability to drive or operate machinery.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Low-dose aspirinIbuprofen can interfere with the antiplatelet effect of low-dose aspirin (particularly when ibuprofen is dosed before aspirin); for patients on low-dose aspirin for cardioprotection consider an analgesic that does not interfere.DailyMed (U.S. National Library of Medicine)
• Warfarin-type (coumarin) anticoagulantsThe effects of warfarin and NSAIDs on GI bleeding are synergistic; users of both have a higher risk of serious GI bleeding than users of either alone; use caution.DailyMed (U.S. National Library of Medicine)
• ACE inhibitorsNSAIDs may diminish the antihypertensive effect of ACE inhibitors.DailyMed (U.S. National Library of Medicine)
• LithiumIbuprofen raised plasma lithium concentrations (mean minimum level +15%) and reduced renal lithium clearance (-19%); observe carefully for lithium toxicity.DailyMed (U.S. National Library of Medicine)
• Pyridostigmine / anticholinesterase agentsMethocarbamol may inhibit the effect of pyridostigmine bromide; use with caution in patients with myasthenia gravis receiving anticholinesterase agents.DailyMed (U.S. National Library of Medicine)
• Alcohol and other CNS depressantsCombined CNS-depressant effects with methocarbamol; patients should be cautioned.DailyMed (U.S. National Library of Medicine)

• Safe use of methocarbamol in pregnancy has not been established; there are reports of fetal and congenital abnormalities after in utero exposure, so it should not be used in women who are or may become pregnant, particularly in early pregnancy, unless the potential benefits outweigh the possible hazards.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• It is not known whether ibuprofen is excreted in human milk; because of the potential for serious adverse reactions in nursing infants, decide whether to discontinue nursing or the drug, taking into account its importance to the mother.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Methocarbamol and/or its metabolites are excreted in the milk of dogs; it is not known whether they are excreted in human milk, so caution should be exercised in nursing women.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Ibuprofen: Inhibits cyclo-oxygenase and prostaglandin synthesis (analgesic, anti-inflammatory and antipyretic actions).
• Methocarbamol: Mechanism not established in humans; may be due to general CNS depression (no direct action on striated muscle).