سعر ميثوكاربكس 10 اقراص 2022

Film-coated oral tablets combining ibuprofen (NSAID) and methocarbamol (muscle relaxant), pack of 10; Egyptian product by Egyphar.

• Ibuprofen: most common include abdominal pain, dyspepsia, nausea, constipation/diarrhoea, flatulence, dizziness, headache, oedema, rash and elevated liver enzymes.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Methocarbamol: drowsiness, dizziness/lightheadedness, sedation, headache, nausea/vomiting, dyspepsia, hypotension, bradycardia, rash/pruritus, blurred vision; rarely anaphylaxis, jaundice, leukopenia and seizures.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Ibuprofen: known hypersensitivity; history of asthma, urticaria or allergic-type reactions after aspirin or other NSAIDs; setting of coronary artery bypass graft (CABG) surgery.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Methocarbamol: hypersensitivity to methocarbamol or any tablet component.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Boxed warning (Ibuprofen): NSAIDs increase the risk of serious cardiovascular thrombotic events (myocardial infarction, stroke) and serious gastrointestinal bleeding, ulceration and perforation, which can be fatal.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Ibuprofen: risk of hepatotoxicity, hypertension, heart failure/oedema, renal toxicity, hyperkalaemia, anaphylaxis and serious skin reactions (including DRESS); avoid in severe heart failure unless benefit outweighs risk.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Methocarbamol may have a general CNS-depressant effect: caution with alcohol and other CNS depressants; may impair mental/physical abilities needed for driving or operating machinery.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Anticoagulants (e.g. warfarin), antiplatelets, SSRIs/SNRIsIncreased risk of serious bleeding with NSAIDs; monitor.DailyMed (U.S. National Library of Medicine)
• ACE inhibitors, ARBs, beta-blockers and diureticsNSAIDs may reduce antihypertensive/diuretic effect and increase risk of renal impairment.DailyMed (U.S. National Library of Medicine)
• LithiumNSAIDs raise plasma lithium levels and reduce renal lithium clearance; monitor for lithium toxicity.DailyMed (U.S. National Library of Medicine)
• MethotrexateNSAIDs may increase methotrexate toxicity; monitor.DailyMed (U.S. National Library of Medicine)
• Alcohol and other CNS depressantsAdditive CNS depression with methocarbamol.DailyMed (U.S. National Library of Medicine)
• Pyridostigmine (anticholinesterases in myasthenia gravis)Methocarbamol may inhibit the effect of pyridostigmine; use with caution.DailyMed (U.S. National Library of Medicine)

• Ibuprofen: avoid at about 30 weeks of gestation and later (premature closure of the fetal ductus arteriosus); use from about 20 weeks may cause fetal renal dysfunction and oligohydramnios - limit dose and duration if needed between 20 and 30 weeks.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Methocarbamol: reports of fetal and congenital abnormalities after in-utero exposure; should not be used in women who are or may become pregnant, particularly in early pregnancy, unless the physician judges benefit outweighs risk.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Methocarbamol: unknown whether excreted in human milk (excreted in dog milk); use with caution while breastfeeding.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Ibuprofen (long-term use): consider periodic CBC and chemistry profile; monitor blood pressure and signs of GI bleeding.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Ibuprofen: Inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis (US label).
• Methocarbamol: Mechanism not clearly identified; may be related to its sedative properties; does not directly relax skeletal muscle (US label).