سعر ايكوزاليب 1جم 20 كبسولة 2026

Icosapent ethyl (ethyl ester of eicosapentaenoic acid, EPA) 1 g oral capsules; Marcyrl Co.; pack of 20 capsules.

• Adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularisation and unstable angina requiring hospitalisation in adults with triglycerides >=150 mg/dL and established cardiovascular disease or diabetes plus 2 or more additional cardiovascular risk factors.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Adjunct to diet to reduce triglyceride levels in adults with severe (>=500 mg/dL) hypertriglyceridaemia.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Cardiovascular outcomes trial: common adverse reactions (>=3% and >=1% more than placebo) were musculoskeletal pain, peripheral oedema, constipation, gout and atrial fibrillation.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypertriglyceridaemia trials: arthralgia and oropharyngeal pain (>=1% more than placebo).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity (e.g. anaphylactic reaction) to icosapent ethyl or any of its components.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Increased risk of atrial fibrillation or flutter requiring hospitalisation (3% vs 2% placebo in the cardiovascular outcomes trial), greater in patients with a history of AF/flutter.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Derived from fish oil: patients with fish or shellfish allergy should be informed of possible allergic reactions and stop the drug and seek care if reactions occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Increased risk of bleeding (12% vs 10% placebo; serious bleeding 3% vs 2%), higher with concomitant antithrombotics such as aspirin, clopidogrel or warfarin.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Anticoagulants and antiplatelet agentsOmega-3 fatty acids may prolong bleeding time; monitor patients taking anticoagulants and/or antiplatelet agents for bleeding.DailyMed (U.S. National Library of Medicine)

• Available data in pregnant women are insufficient to identify a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Omega-3 fatty acids including EPA are present in human milk; no data on effects on the breastfed infant or milk production. Weigh benefits of breastfeeding against the mother's clinical need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Icosapent ethyl: EPA appears to reduce hepatic VLDL-triglyceride synthesis and/or secretion and enhance triglyceride clearance from circulating VLDL (proposed mechanisms include increased beta-oxidation, DGAT inhibition, reduced hepatic lipogenesis and increased lipoprotein lipase activity); cardiovascular-risk mechanisms are not completely understood (US label).