سعر فيبروبيد 600 مجم 30 قرص 2022

Gemfibrozil 600 mg film-coated tablets (Biopharm Egypt), pack of 30.

• Adjunctive therapy to diet for adult patients with very high serum triglyceride levels (Types IV and V hyperlipidemia) who present a risk of pancreatitis and do not respond adequately to diet.Population: AdultsDailyMed (U.S. National Library of Medicine)

• In the Helsinki Heart Study, gastrointestinal reactions were the most frequent (34.2% vs 23.8% placebo), including dyspepsia (19.6%) and abdominal pain (9.8%); acute appendicitis and atrial fibrillation were also more frequent than with placebo.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hepatic or severe renal dysfunction, including primary biliary cirrhosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Preexisting gallbladder disease.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to gemfibrozil.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis: increased risk with combined use with HMG-CoA reductase inhibitors (statins); combination with simvastatin is contraindicated.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• May increase cholesterol excretion into the bile, leading to cholelithiasis; discontinue if gallstones are found.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Anticoagulants: reduce the warfarin dose to maintain the prothrombin time at the desired level and monitor frequently until stabilized.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• HMG-CoA reductase inhibitors (statins); simvastatin contraindicatedIncreased risk of myopathy and rhabdomyolysis; combination with simvastatin is contraindicated.DailyMed (U.S. National Library of Medicine)
• Warfarin and other coumarin anticoagulantsPotentiates anticoagulant effect; reduce anticoagulant dose and monitor prothrombin time frequently.DailyMed (U.S. National Library of Medicine)
• RepaglinideContraindicated: gemfibrozil (strong CYP2C8 inhibitor) markedly increases repaglinide exposure, with risk of severe hypoglycemia.DailyMed (U.S. National Library of Medicine)

• There are no adequate and well-controlled studies in pregnant women; use during pregnancy only if the benefit justifies the potential risk to the fetus (adverse effects seen in animal studies).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Because of the potential for tumorigenicity seen in animal studies, decide whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Gemfibrozil: Lipid regulating agent that decreases serum triglycerides and VLDL cholesterol and increases HDL cholesterol; the mechanism has not been definitely established (US label).