سعر اميونوميد 10 مجم 21 كبسولة 2026

Lenalidomide 10 mg capsules (21 capsules) by Hikma Specialized Pharmaceuticals, Egypt; thalidomide analogue used in haematological malignancies.

• Multiple myeloma in adults, in combination with dexamethasonePopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Maintenance therapy in adults with multiple myeloma after autologous haematopoietic stem cell transplantationPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Transfusion-dependent anaemia due to low- or intermediate-1-risk myelodysplastic syndromes with deletion 5qPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Clinically significant adverse reactions include neutropenia, thrombocytopenia, venous and arterial thromboembolism, second primary malignancies, hepatotoxicity, severe cutaneous reactions and tumour lysis syndrome.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Pregnancy: lenalidomide can cause embryo-fetal harm and is contraindicated in pregnant females.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Severe hypersensitivity (e.g. angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis) to lenalidomide.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning - embryo-fetal toxicity: thalidomide analogue; females of reproductive potential need 2 negative pregnancy tests before starting and must use 2 forms of contraception (or abstain) during and for 4 weeks after treatment; in the US it is available only through a restricted REMS programme.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning - haematologic toxicity: significant neutropenia and thrombocytopenia; dose interruption or reduction may be needed.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning - venous and arterial thromboembolism (DVT, PE, myocardial infarction, stroke) is increased, especially with dexamethasone; thromboprophylaxis is recommended based on risk assessment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• DigoxinCo-administration increased digoxin Cmax and AUC by 14%; periodically monitor digoxin plasma levels.DailyMed (U.S. National Library of Medicine)
• Erythropoietic agents and estrogen-containing therapiesAgents that may increase thrombosis risk should be used with caution after a benefit-risk assessment.DailyMed (U.S. National Library of Medicine)
• WarfarinNo pharmacokinetic interaction, but close monitoring of PT/INR is recommended in MM patients taking warfarin (dexamethasone effect unknown).DailyMed (U.S. National Library of Medicine)

• Based on its mechanism and animal findings (limb abnormalities in monkeys), lenalidomide can cause embryo-fetal harm and is contraindicated during pregnancy; a pregnancy exposure registry exists in the US.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on presence in human milk or effects on the breastfed child; advise women not to breastfeed during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

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