سعر ايموتركسات 2.5مجم 10 اقراص 2024

Imutrexate 2.5 mg tablets (pack of 10): methotrexate, a folate antagonist (dihydrofolate reductase inhibitor) used for certain cancers and for severe rheumatoid arthritis and psoriasis, by Eva Pharma, Egypt. Usually taken ONCE WEEKLY for non-cancer conditions.

• Acute lymphoblastic leukemia (ALL) as part of a combination chemotherapy maintenance regimen.Population: Adults and pediatric patientsDailyMed (U.S. National Library of Medicine)
• Mycosis fungoides.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Relapsed or refractory non-Hodgkin lymphoma as part of a metronomic combination regimen.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Common adverse reactions include ulcerative stomatitis, leukopenia, nausea and abdominal distress.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Pregnant women receiving methotrexate for non-neoplastic diseases.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• History of severe hypersensitivity reactions, including anaphylaxis, to methotrexate.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: serious toxic reactions including death; embryo-fetal toxicity; contraindicated in pregnancy for non-neoplastic disease.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Myelosuppression: can cause severe, life-threatening pancytopenia; obtain blood counts at baseline and periodically.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serious infections, including opportunistic infections, hepatitis B reactivation and tuberculosis, may occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• NSAIDs, aspirin, penicillins, sulfonamides, probenecid, proton pump inhibitors and other drugs that increase methotrexate exposureMay increase methotrexate concentrations and the risk of severe toxicity; if coadministration cannot be avoided, monitor closely.DailyMed (U.S. National Library of Medicine)
• Nitrous oxidePotentiates the effect of methotrexate on folate metabolism; avoid nitrous oxide anesthesia.DailyMed (U.S. National Library of Medicine)
• Folic acid and derivativesDecrease the effectiveness of methotrexate in neoplastic diseases; take only as directed by the prescriber.DailyMed (U.S. National Library of Medicine)

• Methotrexate can cause embryo-fetal toxicity and fetal death; contraindicated in pregnant women with non-neoplastic diseases; verify pregnancy status before starting.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Present in human milk in low amounts; do not breastfeed during treatment and for 1 week after the final dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Methotrexate: Inhibits dihydrofolate reductase, blocking tetrahydrofolate-dependent synthesis of DNA, RNA and proteins (US label 12.1).