سعر ازاثيوبرين بي سي اتش 50مجم 10 اقراص 2022

Azathioprine 50 mg tablets, 10 tablets (1 strip); purine antimetabolite immunosuppressant (Pharmachemie (Netherlands) > Copad Pharma).

• Adjunct for prevention of rejection in renal homotransplantationPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Management of active rheumatoid arthritis to reduce signs and symptomsPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Principal toxicities are haematologic (leukopenia, thrombocytopenia) and gastrointestinal; nausea and vomiting occurred in about 12% of rheumatoid arthritis patients; also infections, malignancy, hepatotoxicity, rare hepatic veno-occlusive disease, skin rash, alopecia, fever, arthralgias and pancreatitis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to azathioprine.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Rheumatoid arthritis patients who are pregnant, or who were previously treated with alkylating agents (cyclophosphamide, chlorambucil, melphalan, others), because of prohibitive malignancy risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: chronic immunosuppression increases the risk of malignancy, including post-transplant lymphoma and hepatosplenic T-cell lymphoma (reported in inflammatory bowel disease patients); prescribers should be familiar with this risk and with the haematologic toxicities.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Skin cancer risk: limit exposure to sunlight and UV light and perform periodic skin examinations.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Cytopenias (leukopenia, thrombocytopenia, anaemias including macrocytic anaemia, pancytopenia), greater in TPMT/NUDT15-deficient patients; serious infections; progressive multifocal leukoencephalopathy; gastrointestinal hypersensitivity reaction.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• AllopurinolAllopurinol inhibits azathioprine inactivation; reduce azathioprine to one-third or one-quarter of the usual dose and consider further reduction or alternatives.DailyMed (U.S. National Library of Medicine)
• FebuxostatConcomitant use is not recommended (xanthine oxidase inhibition).DailyMed (U.S. National Library of Medicine)
• Aminosalicylates (sulfasalazine, mesalazine, olsalazine)May inhibit TPMT; use with caution.DailyMed (U.S. National Library of Medicine)

• Azathioprine can cause fetal harm when given to a pregnant woman; avoid in pregnancy where possible, and it is contraindicated for rheumatoid arthritis in pregnancy. Intrahepatic cholestasis of pregnancy has been reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Nursing is not recommended; 6-mercaptopurine has been detected in the milk of women receiving azathioprine and the potential for serious adverse reactions in nursing infants exists.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Azathioprine: Prodrug converted to 6-mercaptopurine and then to thioguanine nucleotides that interfere with purine synthesis and nucleic acid metabolism, suppressing lymphocyte proliferation; inactivated partly by TPMT and NUDT15 pathways.