سعر امبروفلو 10/40 مجم 20 قرص 2026

Amlodipine 10 mg + olmesartan medoxomil 40 mg film-coated tablets (20 tablets), Inad Pharma, Egypt; fixed-dose antihypertensive combination.

• Treatment of hypertension, alone or with other antihypertensive agents, to lower blood pressurePopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Generally mild; oedema is the main dose-dependent adverse effect (from amlodipine, less frequent when olmesartan is added to amlodipine 10 mg); greater decreases in haemoglobin/haematocrit than with either component.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Do not co-administer aliskiren in patients with diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning - fetal toxicity: drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as possible when pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Symptomatic hypotension in volume- or salt-depleted patients; increased angina or myocardial infarction on starting or increasing the dose (severe obstructive coronary disease); changes in renal function; hyperkalaemia (monitor electrolytes); sprue-like enteropathy with olmesartan (severe chronic diarrhoea with weight loss).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• SimvastatinAmlodipine increases simvastatin exposure; limit simvastatin to 20 mg daily.DailyMed (U.S. National Library of Medicine)
• Cyclosporine, tacrolimusAmlodipine may increase their exposure; monitor trough levels and adjust dose.DailyMed (U.S. National Library of Medicine)
• Moderate/strong CYP3A inhibitorsIncrease amlodipine exposure; monitor for hypotension and oedema.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm: RAS-acting drugs in the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death (oligohydramnios, skull hypoplasia, anuria, renal failure); discontinue when pregnancy is detected and consider alternative therapy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Amlodipine is present in human milk and olmesartan in rat milk; breastfeeding is not recommended during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

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