سعر ايراستابكس كو 5/40 مجم 30 قرص 2024

Erastapex Co 5/40 mg (Amlodipine + Olmesartan medoxomil) 5 mg/40 mg film-coated tablets, pack of 30, by Multi-Apex (Egypt).

• Treatment of hypertension, alone or with other antihypertensive agents, to lower blood pressure; may also be used as initial therapy in patients likely to need multiple antihypertensive agents.Population: AdultsDailyMed (U.S. National Library of Medicine)

• The most common adverse reaction (incidence ≥ 3%) was oedema.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Do not co-administer aliskiren with this product in patients with diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fetal toxicity (boxed warning): drugs acting directly on the renin-angiotensin system during the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death; discontinue as soon as possible when pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Symptomatic hypotension may occur after initiation in volume- or salt-depleted patients (e.g. on high-dose diuretics); correct depletion before starting or start under close medical supervision.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Patients, particularly those with severe obstructive coronary artery disease, may develop increased frequency, duration or severity of angina or acute myocardial infarction on starting or increasing the dose of a calcium channel blocker such as amlodipine.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• SimvastatinCo-administration with amlodipine increases simvastatin exposure; limit simvastatin to 20 mg daily.DailyMed (U.S. National Library of Medicine)
• Cyclosporine / tacrolimusAmlodipine may increase systemic exposure of cyclosporine or tacrolimus; monitor trough blood levels and adjust the immunosuppressant dose when appropriate.DailyMed (U.S. National Library of Medicine)
• CYP3A inhibitors (moderate and strong)Increase systemic exposure to amlodipine; monitor for symptoms of hypotension and oedema and consider dose adjustment.DailyMed (U.S. National Library of Medicine)

• Fetal toxicity (boxed warning): drugs acting directly on the renin-angiotensin system during the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death; discontinue as soon as possible when pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Amlodipine: Inhibits transmembrane calcium influx into vascular smooth muscle and cardiac muscle; peripheral arterial vasodilator.
• Olmesartan medoxomil: Prodrug hydrolysed to olmesartan, which blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II at the AT1 receptor.