سعر كيميفورج 320/10 مجم 20 قرص 2023

Kemiforge amlodipine 10 mg / valsartan 320 mg film-coated tablets, pack of 20, by Chemipharm (Egypt).

• Hypertension in patients not adequately controlled on monotherapy.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Initial therapy of hypertension in patients likely to need multiple drugs to reach blood pressure goals.Population: AdultsDailyMed (U.S. National Library of Medicine)

• In placebo-controlled trials: peripheral oedema 5.4%, nasopharyngitis 4.3%, upper respiratory tract infection 2.9%, dizziness 2.1%.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to any component.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Coadministration with aliskiren in patients with diabetes.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Symptomatic hypotension may occur, especially in volume- or salt-depleted patients (e.g. high-dose diuretics); correct depletion before starting.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Worsening angina or acute myocardial infarction can rarely occur on starting or increasing amlodipine, particularly with severe obstructive coronary artery disease.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Changes in renal function including acute renal failure may occur, particularly with renal artery stenosis, heart failure or volume depletion; hyperkalaemia may occur.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• CYP3A inhibitors (moderate and strong)Increase amlodipine exposure; monitor for hypotension and oedema.DailyMed (U.S. National Library of Medicine)
• CYP3A inducersMay decrease amlodipine levels; monitor blood pressure.DailyMed (U.S. National Library of Medicine)
• SildenafilMonitor for hypotension when co-administered with amlodipine.DailyMed (U.S. National Library of Medicine)

• Boxed warning: fetal toxicity. Drugs acting directly on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as pregnancy is detected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Amlodipine: Inhibits transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, causing peripheral arterial vasodilation (US label).
• Valsartan: Blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking its binding to the AT1 receptor (US label).