سعر انهيرين بلس 150 / 12.5 مجم 10 أقراص 2022

Inherin plus 150/12.5 mg (Marcyrl): film-coated tablets of aliskiren 150 mg (direct renin inhibitor) with hydrochlorothiazide 12.5 mg (thiazide diuretic), pack of 10.

• Treatment of hypertension, to lower blood pressure (as add-on, replacement or initial therapy).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>=1.5% and more than placebo): dizziness and diarrhoea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Do not use with ARBs or ACE inhibitors in patients with diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Anuria, or hypersensitivity to sulfonamide-derived drugs (such as hydrochlorothiazide) or to any component.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning - fetal toxicity: drugs acting directly on the renin-angiotensin system can injure and kill the developing fetus; discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Avoid combination with ARBs or ACE inhibitors, particularly when CrCl <60 mL/min (renal impairment, hyperkalaemia, hypotension).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Anaphylactic reactions and head and neck angioedema; hypotension in volume- or salt-depleted patients (correct first); monitor serum creatinine and potassium; acute myopia and secondary angle-closure glaucoma (hydrochlorothiazide).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Cyclosporine or itraconazoleAvoid concomitant use with aliskiren (increased aliskiren exposure).DailyMed (U.S. National Library of Medicine)
• NSAIDsIncreased risk of renal impairment and loss of antihypertensive effect.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased risk of lithium toxicity with diuretics.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm: renin-angiotensin system drugs in the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death; thiazides cross the placenta (risk of fetal/neonatal jaundice and thrombocytopenia).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on aliskiren in human milk; hydrochlorothiazide is present in human milk. Breastfeeding is not recommended during treatment (risk of hypotension, electrolyte imbalance and renal impairment in the infant).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Aliskiren: Directly inhibits renin, reducing conversion of angiotensinogen to angiotensin I and downstream angiotensin II formation.
• Hydrochlorothiazide: Inhibits sodium chloride reabsorption in the distal convoluted tubule, increasing sodium and water excretion.