سعر كيتوريست 150 مجم اس ار 10 اقراص 2022

Ketorest: ketoprofen 150 mg sustained-release film-coated tablets, pack of 10 (Jedco International, Egypt). NSAID analgesic and anti-inflammatory.

• Minor gastrointestinal effects predominate (upper GI more than lower GI), followed by CNS effects such as headache, dizziness or drowsiness; peptic ulcer or GI bleeding occurred in under 1% of patients in controlled trials and in over 2% in open-label continuation studies.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to ketoprofen; history of asthma, urticaria or allergic-type reactions after aspirin or other NSAIDs (severe, rarely fatal anaphylactic reactions reported); use in the setting of coronary artery bypass graft (CABG) surgery.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Boxed warning (US): NSAIDs increase the risk of serious cardiovascular thrombotic events (myocardial infarction, stroke), which can be fatal, may occur early and may increase with duration of use; NSAIDs also increase the risk of serious gastrointestinal bleeding, ulceration and perforation, which can occur at any time without warning; elderly patients are at greater risk of serious GI events.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• ACE inhibitorsNSAIDs may diminish the antihypertensive effect of ACE inhibitors.DailyMed (U.S. National Library of Medicine)
• AspirinAspirin decreased ketoprofen protein binding and increased its clearance; concomitant use is not generally recommended because of the potential for increased adverse effects.DailyMed (U.S. National Library of Medicine)
• Diuretics (furosemide, thiazides)NSAIDs can reduce the natriuretic effect of loop and thiazide diuretics and increase the risk of renal failure; observe for renal failure and diuretic efficacy.DailyMed (U.S. National Library of Medicine)
• LithiumNSAIDs raise plasma lithium levels and reduce renal lithium clearance; observe for lithium toxicity.DailyMed (U.S. National Library of Medicine)
• MethotrexateKetoprofen may reduce methotrexate elimination, raising serum levels and toxicity; use with caution.DailyMed (U.S. National Library of Medicine)
• ProbenecidProbenecid reduces ketoprofen plasma clearance to about one-third and decreases its protein binding; the combination is not recommended.DailyMed (U.S. National Library of Medicine)
• WarfarinWarfarin and NSAIDs have synergistic effects on GI bleeding; concurrent therapy requires close monitoring.DailyMed (U.S. National Library of Medicine)

• NSAID use can cause premature closure of the fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios and, in some cases, neonatal renal impairment; limit dose and duration between about 20 and 30 weeks of gestation and avoid use from about 30 weeks onward.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Not known whether ketoprofen is excreted in human milk; the US label states it is not recommended for use in nursing mothers.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Ketoprofen: Ketoprofen is a non-steroidal anti-inflammatory drug (propionic acid derivative); like other NSAIDs it inhibits prostaglandin synthesis.