سعر ميباكوفين 150مجم 20 اقراص 2024

Ketoprofen 150 mg long-acting tablets (Mepaco, Egypt), a propionic acid derivative non-steroidal anti-inflammatory drug (NSAID); 20 tablets per pack.

• Most frequent adverse reactions in controlled trials of ketoprofen ER capsules were gastrointestinal, mainly dyspepsia (about 11%), plus nausea, abdominal pain, diarrhoea, constipation and flatulence; headache and CNS effects were also reported.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to ketoprofen or any component.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• History of asthma, urticaria or other allergic-type reactions after taking aspirin or other NSAIDs (severe, sometimes fatal, anaphylactic reactions reported).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• In the setting of coronary artery bypass graft (CABG) surgery.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Boxed warning: NSAIDs increase the risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal; the risk may occur early in treatment and may increase with duration of use.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Boxed warning: NSAIDs increase the risk of serious gastrointestinal adverse events, including bleeding, ulceration and perforation of the stomach or intestines, which can be fatal and can occur at any time without warning; elderly patients and those with prior peptic ulcer disease or GI bleeding are at greater risk.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Use with caution in hypertension and heart failure: NSAIDs can cause new-onset or worsening hypertension and fluid retention/oedema; avoid in severe heart failure unless benefits outweigh risks.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Renal toxicity and hyperkalaemia: long-term NSAID use may cause renal papillary necrosis and other renal injury; not recommended in advanced renal disease; monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or taking diuretics or ACE inhibitors.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Hepatotoxicity: elevations of liver enzymes and rare severe hepatic reactions have been reported; discontinue if signs of liver disease develop.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Serious skin reactions (exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) and DRESS can occur; discontinue at the first appearance of skin rash or hypersensitivity.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Fetal toxicity: avoid NSAIDs in pregnant women at about 30 weeks of gestation and later (premature closure of the fetal ductus arteriosus); if needed between about 20 and 30 weeks, limit to the lowest effective dose and shortest duration because of the risk of oligohydramnios/fetal renal dysfunction.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Safety and effectiveness in pediatric patients under 18 years have not been established.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• ACE inhibitors / angiotensin receptor blockersNSAIDs may diminish the antihypertensive effect and, in elderly, volume-depleted or renally impaired patients, may cause deterioration of renal function.DailyMed (U.S. National Library of Medicine)
• AspirinConcomitant use is not generally recommended because of increased GI adverse reactions; ketoprofen is not a substitute for low-dose aspirin cardiovascular prophylaxis.DailyMed (U.S. National Library of Medicine)
• Diuretics (loop and thiazide)NSAIDs can reduce the natriuretic effect of furosemide and thiazides; observe for renal failure and diuretic efficacy.DailyMed (U.S. National Library of Medicine)
• LithiumNSAIDs raise plasma lithium concentrations and reduce renal lithium clearance; monitor for lithium toxicity.DailyMed (U.S. National Library of Medicine)
• MethotrexateNSAIDs may enhance methotrexate toxicity; use caution.DailyMed (U.S. National Library of Medicine)
• ProbenecidProbenecid markedly increases ketoprofen plasma levels; concomitant use is not recommended.DailyMed (U.S. National Library of Medicine)
• Warfarin and other anticoagulantsThe effects of warfarin and NSAIDs on GI bleeding are synergistic; monitor closely.DailyMed (U.S. National Library of Medicine)

• Use of NSAIDs at about 30 weeks of gestation and later increases the risk of premature closure of the fetal ductus arteriosus; use at about 20 weeks or later has been associated with fetal renal dysfunction leading to oligohydramnios.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Nursing mothers: use of ketoprofen extended-release capsules is not recommended while nursing (US label).General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Ketoprofen: Non-steroidal anti-inflammatory drug with analgesic and antipyretic properties; its action, like other NSAIDs, is thought to involve inhibition of prostaglandin synthesis (US label).