سعر لامبروفلام 100مجم 20 قرص 2022

Lambroflam: aceclofenac 100 mg film-coated tablets, pack of 20, by EGPI (Pioneer) (Egypt market); NSAID.

• Relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.Population: Adultselectronic medicines compendium (emc), UK

• Common: dizziness, dyspepsia, abdominal pain, nausea, diarrhoea and hepatic enzyme increased. Also reported: GI haemorrhage/ulceration/perforation, severe mucocutaneous reactions; NSAID class effects include GI ulceration/bleeding, hypersensitivity reactions, oedema and hypertension.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to aceclofenac or any excipient; patients in whom aspirin or other NSAIDs precipitate asthma, bronchospasm, acute rhinitis or urticaria.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Active or history of recurrent peptic ulcer/haemorrhage; history of GI bleeding or perforation related to previous NSAID therapy; active bleeding or bleeding disorders.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Hepatic or renal failure; established congestive heart failure (NYHA II-IV), ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease.International label, equivalent formulation · electronic medicines compendium (emc), UK

• GI bleeding, ulceration and perforation, which can be fatal, may occur at any time with or without warning symptoms; risk higher with higher doses, history of ulcer and in the elderly; consider gastroprotection.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Cardiovascular and cerebrovascular: aceclofenac is structurally related to diclofenac and may carry a similar increased risk of arterial thrombotic events; fluid retention, hypertension and oedema have been reported.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Serious skin reactions (including Stevens-Johnson syndrome and toxic epidermal necrolysis) have been reported very rarely; stop at the first appearance of rash or mucosal lesions.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Other NSAIDs including aspirin and COX-2 inhibitors; corticosteroidsConcomitant use increases the risk of GI ulceration or bleeding; avoid combining NSAIDs.electronic medicines compendium (emc), UK
• Anticoagulants (e.g. warfarin), antiplatelet agents and SSRIsNSAIDs may enhance the effect of anticoagulants and increase bleeding risk with antiplatelets/SSRIs; monitor closely.electronic medicines compendium (emc), UK
• Lithium, methotrexate, digoxin, ciclosporin and tacrolimusNSAIDs inhibit renal clearance of lithium and cardiac glycosides such as digoxin (avoid unless levels can be monitored frequently); consider the methotrexate interaction even at low doses (monitor renal function); ciclosporin or tacrolimus may increase nephrotoxicity (monitor renal function).electronic medicines compendium (emc), UK

• During the first and second trimester aceclofenac should not be given unless clearly necessary; from week 20 NSAIDs may cause oligohydramnios from foetal renal dysfunction; contraindicated in the third trimester (risk of premature ductus arteriosus closure, prolonged bleeding and inhibited uterine contractions).International label, equivalent formulation · electronic medicines compendium (emc), UK
• No information on excretion of aceclofenac into human milk; use during breast-feeding should be avoided unless the benefit outweighs the risk.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Aceclofenac: NSAID with anti-inflammatory and analgesic properties; mode of action largely based on inhibition of prostaglandin synthesis (cyclo-oxygenase inhibition) (UK Preservex SmPC 5.1).